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Journal of Analytical Chemistry

, Volume 74, Issue 3, pp 248–254 | Cite as

Derivatization of Ions under the Conditions of Surface Assisted Laser Desorption/Ionization

  • A. A. GrechnikovEmail author
  • A. S. Borodkov
  • S. M. Nikiforov
ARTICLES
  • 7 Downloads

Abstract

A method for the chemical modification (derivatization) of ions obtained by surface assisted laser desorption/ionization (SALDI) is proposed. Derivatization is based on the interaction of desorbed ions with alcohol molecules. The method is simple, does not affect the duration of analysis and ensures the improvement of the analytical characteristics of the SALDI method, when analysis is carried out under the conditions of peak interference and strong fragmentation of analyte ions. The efficiency of the method is demonstrated in the determination of caffeine, pyrrolidine, and diphenhydramine under the conditions of atmospheric pressure sample application.

Keywords:

mass spectrometry surface assisted laser desorption/ionization modification of ions determination of organic compounds 

Notes

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • A. A. Grechnikov
    • 1
    Email author
  • A. S. Borodkov
    • 1
  • S. M. Nikiforov
    • 2
  1. 1.Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of SciencesMoscowRussia
  2. 2.Prokhorov Institute of General Physics, Russian Academy of SciencesMoscowRussia

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