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Journal of Analytical Chemistry

, Volume 73, Issue 14, pp 1323–1326 | Cite as

Silylation with the Generation of a Fixed Charge for the Analysis of Alcohols by MALDI and SALDI Mass Spectrometry

  • D. I. ZhilyaevEmail author
  • L. G. Voskresensky
  • N. Yu. Polovkov
  • R. S. Borisov
ARTICLES
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Abstract

A new method of the derivatization of alcohols for their analysis by matrix-assisted laser desorption/ionization (MALDI) and surface-assisted laser desorption/ionization (SALDI) is proposed. The approach is based on the silylation of the analytes with bromomethylchlorodimethylsilane in the presence of tertiary amines to yield fixed-charge containing derivatives. The proposed method was tested using aliphatic alcohols, terpenols, and sterols. MALDI and SALDI mass spectra of all derivatives contain intense ion peaks corresponding to their cationic parts.

Keywords:

MALDI mass spectrometry SALDI alcohols steroids derivatization fixed charge 

Notes

ACKNOWLEDGMENTS

The work was supported by the Federal Agency for Scientific Organizations of Russian Federation within the framework of the State assignment of the Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, no. 79.

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Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • D. I. Zhilyaev
    • 1
    Email author
  • L. G. Voskresensky
    • 1
  • N. Yu. Polovkov
    • 2
  • R. S. Borisov
    • 1
    • 2
  1. 1.People’s Friendship University of RussiaMoscowRussia
  2. 2.Topchiev Institute of Petrochemical Synthesis, Russian Academy of SciencesMoscowRussia

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