Silylation with the Generation of a Fixed Charge for the Analysis of Alcohols by MALDI and SALDI Mass Spectrometry
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A new method of the derivatization of alcohols for their analysis by matrix-assisted laser desorption/ionization (MALDI) and surface-assisted laser desorption/ionization (SALDI) is proposed. The approach is based on the silylation of the analytes with bromomethylchlorodimethylsilane in the presence of tertiary amines to yield fixed-charge containing derivatives. The proposed method was tested using aliphatic alcohols, terpenols, and sterols. MALDI and SALDI mass spectra of all derivatives contain intense ion peaks corresponding to their cationic parts.
Keywords:MALDI mass spectrometry SALDI alcohols steroids derivatization fixed charge
The work was supported by the Federal Agency for Scientific Organizations of Russian Federation within the framework of the State assignment of the Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, no. 79.
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