Novel Reactive Matrices for the Analysis of Alcohols by Matrix-Assisted Laser Desorption/Ioization Mass Spectrometry
A possibility of using a number of aromatic and heteroaromatic carboxylic acids and their halogen anhydrides as reactive matrix compounds for the analysis of alcohols of different structures by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry has been studied. It is shown that the acylation of alcohols with nicotinic and quinoline-6-carboxylic acid chlorides gives derivatives with high desorption/ionization efficiency under MALDI conditions, and that the free acids formed as a result of the hydrolysis of anhydrides act as matrix compounds. The proposed approach is tested on a number of aliphatic, alicyclic, and aromatic alcohols.
Keywords:reactive matrix derivatization acylation alcohols aromatic acids heteroaromatic acids diols MALDI mass spectrometry
The work was carried out within the framework of the State Task of the Institute of Petrochemical Synthesis RAS with the financial support of the Federal Agency of Scientific Organization of the Russian federation. The works on the optimization of the procedures for obtaining alcohol derivatives were carried out with the financial support of the Russian Foundation for Basic Research, project no. 18-33-00729.