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Journal of Analytical Chemistry

, Volume 73, Issue 13, pp 1269–1274 | Cite as

An Improved Procedure for the Gas Chromatography–Tandem Mass Spectrometry Detection of the Globin Adduct of Sulfur Mustard

  • N. L. KoryaginaEmail author
  • M. D. Shachneva
  • A. I. Ukolov
  • E. I. Savel’eva
  • N. S. Khlebnikova
  • A. S. Radilov
ARTICLES
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Abstract

Features of the electron and chemical ionization mass spectra of derivatives of N-[2-[(hydroxyethyl)thio]ethyl]-DL-valine (НЕТЕ-Val)—a biomarker of sulfur mustard—recorded by GC–MS and GC–MS/MS are studied. The retention indices of the studied derivatives were measured. An optimized procedure of the GC–MS/MS (MRM mode) identification of НЕТЕ-Val was tested in the analysis of donor blood samples in vitro exposed to sulfur mustard. The linear range of the detector was from 10 to 100 ng mL–1, and the limit of detection for sulfur mustard was 10 ng mL–1.

Keywords:

gas chromatography–mass spectrometry sulfur mustard globin adduct 

Notes

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Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • N. L. Koryagina
    • 1
    Email author
  • M. D. Shachneva
    • 1
  • A. I. Ukolov
    • 1
  • E. I. Savel’eva
    • 1
  • N. S. Khlebnikova
    • 1
  • A. S. Radilov
    • 1
  1. 1.Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agency of RussiaKuzmolovskyRussia

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