Journal of Analytical Chemistry

, Volume 73, Issue 12, pp 1202–1208 | Cite as

Highly Selective Solid Contact Sensor for Low Level Concentration Measurements of Iron(III) in Pharmaceutical and Biological Media

  • Bita ShafaatianEmail author
  • S. Ommolbanin Sadati
  • Ahmad Soleymanpour
  • Fatemeh Amouzad


A symmetrical tetradentate Schiff base ligand was derived by the condensation of the corresponding o-vanillin with urea. The synthesized Schiff base ligand was studied to characterize its ability as a cation carrier in poly(vinylchloride) membrane solid contact sensor. The constructed sensor showed excellent response characteristics to iron(III) ion. The electrode exhibited Nernstian slope of 19.5 mV/decade over a wide concentration range of iron(III) from 3.0 × 10–6 to 1.3 × 10–2 M with a detection limit of 1.2 × 10–6 M. The sensor has fast response time, good reproducibility and excellent selectivity toward iron(III) ion with respect to many alkali, alkaline earth, transition and heavy metal ions. The potentiometric response of the sensor is independent of pH of the test solution in the range of 2.5–4.5. The applicability of the sensor was investigated by the determination of iron(III) concentration in pharmaceutical, biological and water samples.


iron(III), tetradentate ligand sensor, determination, potentiometry 



We gratefully acknowledge the support of this work by Damghan University Research Council.


  1. 1.
    Kilic, A., Tas, E., and Deveci, B., Polyhedron, 2007, vol. 26, p. 4009.CrossRefGoogle Scholar
  2. 2.
    Shamspur, T., Sheikhshoaie, I., and Mashhadiza-deh, M.H., J. Anal. At. Spectrom., 2005, vol. 20, p. 476.CrossRefGoogle Scholar
  3. 3.
    Shemirani, F., Dehghan Abkenar, S., Mirroshandel, A.A., Niasari, M.S., and Kozania, R.R., Anal. Sci., 2003, vol. 19, p. 1453.CrossRefGoogle Scholar
  4. 4.
    Faridbod, F., Ganjali, M.R., Dinarvand, R., Norouzi, P., and Riahi, S., Sensors, 2008, vol. 8, p. 1645.CrossRefGoogle Scholar
  5. 5.
    Dhahagani, K., Mathan Kumar, S., Chakkaravar-thi, G., Anitrha, K., Rajesh, J., Ramu, A., and Rajagopal, G., Spectrochim. Acta, Part A, 2014, vol. 117, p. 87.CrossRefGoogle Scholar
  6. 6.
    Shebl, M., Spectrochim. Acta, Part A, 2014, vol. 117, p. 127.CrossRefGoogle Scholar
  7. 7.
    Santos, J.E., Dockal, E.R., and Kavalheiro, E.T.G., J. Therm. Anal. Calorim., 2003, vol. 79, p. 243.CrossRefGoogle Scholar
  8. 8.
    Goel, P., Kumar, D., and Chandra, S.S., J. Chem. Biol. Phys. Sci., 2014, vol. 4, p. 1946.Google Scholar
  9. 9.
    Greenwood, N.N. and Earnshaw, A., Chemistry of the Elements, Oxoford: Pergamon, 1984.Google Scholar
  10. 10.
    Wintrole, M., Clinical Hematology, Philadelphia: Lea & Febiger, 1961.Google Scholar
  11. 11.
    Porter, J., Hematol. Oncol. Clin. North Am., 2005, vol. 19, p. 7.Google Scholar
  12. 12.
    Cabantchik, Z.I., Breuer, W., Zanninelli, G., and Cianciulli, P., Best Pract. Res., Clin. Haematol., 2005, vol. 18, p. 277.CrossRefGoogle Scholar
  13. 13.
    Ion Selective Electrodes in Analytical Chemistry, Freiser, H., Ed., New York: Plenum, 1980, vol. 2.Google Scholar
  14. 14.
    Mikhelson, K.M., Ion-Selective Electrode, Berlin: Springer, 2013.CrossRefGoogle Scholar
  15. 15.
    Ma, Y.-H., Yuan, R., Chai, Y.-Q., Wu, X., Zhou, W., Liu, X.-L., and Deng, F., Anal. Lett., 2009, vol. 42, p. 2411.CrossRefGoogle Scholar
  16. 16.
    Shamsipur, M., Soleymanpour, A., Akhond, M., Sharghi, H., and Hosseini Sarvari, M., Electroanalysis, 2005, vol. 17, p. 776.CrossRefGoogle Scholar
  17. 17.
    Ganjali, M.R., Norouzi, P., Faridbod, F., Ghorbani, M., and Adib, M., Anal. Chim. Acta, 2006, vol. 569, p. 35.CrossRefGoogle Scholar
  18. 18.
    Mashhadizadeh, M.H., SheikhShoaei, I., and Monadi, N., Talanta, 2004, vol. 64, p. 1048.CrossRefGoogle Scholar
  19. 19.
    Abbaspour, A., Esmaeilbeig, A.R., Jarrahpour, A.A., Khajeh, B., and Kia, R., Talanta, 2002, vol. 58, p. 397.CrossRefGoogle Scholar
  20. 20.
    Gupta, V.K., Singh, A.K., and Gupta, B., Anal. Chim. Acta, 2006, vol. 575, p. 198.CrossRefGoogle Scholar
  21. 21.
    Ganjali, M.R., Kiani-Anbouhi, R., Shamsipur, M., Poursaberi, T., Salavati-Niasari, M., Talebpour, Z., and Emami, M., Electroanalysis, 2004, vol. 16, p. 1002.CrossRefGoogle Scholar
  22. 22.
    Ganjali, M.R., Qomi, M., Daftari, A., Norouzi, P., Salavati-Niasari, M., and Rabbani, M., Sens. Actuators, B, 2004, vol. 98, p. 92.CrossRefGoogle Scholar
  23. 23.
    Ganjali, M.R., Emami, M., Rezapour, M., Shamsipur Maddah, M.B., Salavati-Niasari, M., Hosseini, M., and Talebpour, Z., Anal. Chim. Acta, 2003, vol. 495, p. 51.CrossRefGoogle Scholar
  24. 24.
    Ohashi, Y., Bull. Chem. Soc. Jpn., 1997, vol. 70, p. 1319.CrossRefGoogle Scholar
  25. 25.
    Xinde, Z., Chenggang, W., and Zhiping, L., Synth. Inorg. Met.-Org. Chem., 1996, vol. 26, p. 955.Google Scholar
  26. 26.
    Shafaatian, B. and Maasoumi, E., J. Chin. Chem. Soc., 2015, vol. 62, p. 349.CrossRefGoogle Scholar
  27. 27.
    Nour, E.M., Taha, A., and Alnaimi, I.S., Inorg. Chim. Acta, 1988, vol. 141, p. 139.CrossRefGoogle Scholar
  28. 28.
    Wang, W., Zeng, F.L., and Wang, X., Polyhedron, 1996, vol. 15, p. 1699.CrossRefGoogle Scholar
  29. 29.
    Malon, A., Radu, A., Qin, W., Qin, Y., Ceresa, A., Maj-Zurawska, M., Bakker, E., and Pretsch, E., Anal. Chem., 2003, vol. 75, p. 3865.CrossRefGoogle Scholar
  30. 30.
    Soleymanpour, A., Shafaatian, B., Kor, K., and Hasaninejad, A.R., Monatsh. Chem., 2012, vol. 143, p. 181.CrossRefGoogle Scholar
  31. 31.
    Bakker, E., Buhlmann, P., and Pretch, E., Chem. Rev., 1997, vol. 97, p. 3083.CrossRefGoogle Scholar
  32. 32.
    Hodinar, A. and Jyo, A., Anal. Chem., 1989, vol. 61, p. 1169.CrossRefGoogle Scholar
  33. 33.
    Soleymanpour, A., Abdifar, S., and Bani, R., Electroanalysis, 2011, vol. 23, p. 2813.CrossRefGoogle Scholar
  34. 34.
    Umezawa, Y., Umezawa, K., and Sato, H., Pure Appl. Chem., 1995, vol. 67, p. 507.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • Bita Shafaatian
    • 1
    Email author
  • S. Ommolbanin Sadati
    • 1
  • Ahmad Soleymanpour
    • 1
    • 2
  • Fatemeh Amouzad
    • 1
  1. 1.School of Chemistry, Damghan UniversityDamghanIran
  2. 2.Institute of Biological Science, Damghan UniversityDamghanIran

Personalised recommendations