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Russian Journal of Electrochemistry

, Volume 55, Issue 5, pp 419–428 | Cite as

Synthesis, Characterization, in vitro Antifungal Activities and Calf Thymus DNA Interactions of Two Different Hydroxy Benzaldehyde Derivative Schiff Bases from Sulfamethizole: Electrochemical, Spectroscopic and Biological Study

  • Ender BiçerEmail author
  • Vahide Pehlivan
  • Yeliz Genç Bekiroğlu
Article
  • 9 Downloads

Abstract

In the present work, the Schiff bases were synthesized by reacting sulfamethizole (SMTZ) with two different hydroxy benzaldehydes (2,3-dihydroxy benzaldehyde (DHBA) and 2,4,6-trihydroxy benzaldehyde (THBA)) and characterized by elemental analysis, 1H-NMR and IR spectroscopies. From the obtained data, it was suggested that 4,6-dihydroxy salicylaldehyde reacted with both primary and secondary amine groups of SMTZ. The binding properties between the synthesized Schiff bases and calf thymus DNA (CT-DNA) at the physiological pH (7.4) was investigated by using cyclic voltammetry and UV-Vis spectroscopy techniques. The experimental results verify that the Schiff bases can bind to CT-DNA by electrostatic mode in 1 : 1 stoichiometry. Antifungal activities of the synthesized Schiff bases against Candida albicans ATCC 10231 were studied and their minimum inhibitory concentrations (MIC) were also determined. The MIC value of the Schiff base 1 synthesized from DHBA is smaller than that of the Schiff base 2 obtained from THBA. Although Schiff base 2 binds to CT-DNA with a higher affinity than Schiff base 1, it is less effective than Schiff base 1 against Candida albicans.

Keywords

calf thymus DNA interaction salicylaldehyde derivatives Schiff bases sulfamethizole 

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Notes

Acknowledgments

This study was presented in part and in poster form at International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018), 26–27 April 2018, Ankara/TURKEY.

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • Ender Biçer
    • 1
    Email author
  • Vahide Pehlivan
    • 1
  • Yeliz Genç Bekiroğlu
    • 2
  1. 1.Department of Chemistry, Faculty of Arts and SciencesOndokuz Mayıs UniversityAtakum-SamsunTurkey
  2. 2.Department of Herbal and Animal Production, Bafra Vocational SchoolOndokuz Mayıs UniversityBafra-SamsunTurkey

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