Russian Journal of Genetics

, Volume 54, Issue 12, pp 1479–1486 | Cite as

Genetic Factors of Comorbidity of Pelvic Organ Prolapse, Stress Urinary Incontinence, and Chronic Venous Insufficiency of the Lower Limbs in Women

  • M. B. KhadzhievaEmail author
  • S. V. Kamoeva
  • A. V. Ivanova
  • L. E. Salnikova


A genetic association study was carried out to test for a correlation between polymorphic variants of genes involved in the organization of elastic fibers (FBLN5, LOXL1, ELN, and FBN1) and multiple forms of connective tissue (CT) pathology, including pelvic organ prolapse (POP), stress urinary incontinence (SUI), and chronic venous insufficiency of the lower limbs (CVI). The FBLN5 haplotype rs12586948(A)-rs2284337(A)-rs2430347(A)-rs2430369(C), associated with a high risk for each of the studied CT disorders, was identified. For SUI and POP, common risk FBLN5 haplotype rs12586948(A)-rs2284337(A)-rs2430347(A)-rs2498841(G)-rs2018736(C)-rs2430369(C)-rs2245701(G) was detected. These allele groups, as well as the LOXL1 haplotype rs2165241(C)-rs2304719(T)-rs2415231(C), correlated with an increase in the number of coexisting connective tissue pathologies (POP, SUI, and CVI). Thus, an association between the FBLN5 and LOXL1 haplotypes and the CT disease comorbidity was identified.


pelvic organ prolapse stress urinary incontinence chronic venous insufficiency of the lower limbs comorbidity the FBLN5 and LOXL1 genes 



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Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • M. B. Khadzhieva
    • 1
    • 2
    • 3
    Email author
  • S. V. Kamoeva
    • 4
    • 5
  • A. V. Ivanova
    • 6
  • L. E. Salnikova
    • 1
    • 2
    • 3
  1. 1.Vavilov Institute of General Genetics, Russian Academy of SciencesMoscowRussia
  2. 2.Rogachev National Research Center of Pediatric Hematology, Oncology, and ImmunologyMoscowRussia
  3. 3.Federal Research and Clinical Center of Intensive Care Medicine and RehabilitologyMoscowRussia
  4. 4.Pirogov Russian National Research Medical UniversityMoscowRussia
  5. 5.Central Clinical Hospital of the Russian Academy of SciencesMoscowRussia
  6. 6.Center of Gynecology, Reproductive and Aesthetic MedicineKrasnogorsk raionRussia

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