Human Physiology

, Volume 45, Issue 6, pp 693–700 | Cite as

Effects of Melatonin on the Oxygen Transport in Blood, Gas Transmitters, and Prooxidant–Antioxidant Balance in the Exercise

  • V. V. ZinchukEmail author
  • I. A. Poluyan
  • S. V. Hlutkin


We studied the effects of melatonin on the oxygen transport in blood and prooxidant−antioxidant balance in males aged from 18 to 21 years in submaximal physical exercise. The subjects received 3 mg of melatonin once a day for two months. As a result of melatonin administration, we observed a shift of oxyhemoglobin dissociation to the right, which results in reduced manifestation of oxidative stress after physical exercise. We found that the increased level of gas transmitters (nitrogen monoxide and hydrogen sulfide) after melatonin administration can influence oxygen transport in blood and prooxidant–antioxidant balance in exercise.


physical exercise melatonin oxygen lipid peroxidation antioxidants gas transmitters 



We thank the staff of the research group for the study of the gas transmission function of blood in the research part of the Grodno State Medical University.


This study was supported by project no. 20 170 643.


Conflict of interests. The authors declare no obvious and potential conflicts of interest related to the publication of this article.

Statement of compliance with standards of research involving humans as subjects. All studies were conducted in accordance with the principles of biomedical ethics, formulated in the Helsinki Declaration of 1964 and its subsequent updates, and approved by the local bioethical committee of the Grodno State Medical University (Grodno, Belarus). Each research participant presented a voluntary written informed consent, signed by him after explaining to him the potential risks and benefits, as well as the nature of the upcoming research.


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Copyright information

© Pleiades Publishing, Inc. 2019

Authors and Affiliations

  • V. V. Zinchuk
    • 1
    Email author
  • I. A. Poluyan
    • 1
  • S. V. Hlutkin
    • 1
  1. 1.Grodno State Medical UniversityGrodnoBelarus

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