Search for Blood Proteome Proteins Involved in the Regulation of Bone Remodeling in Astronauts
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On the basis of proteomics, modern data on the features of bone remodeling in astronauts after long-term space flights are presented. We describe the regulatory proteins of the blood proteome that are significantly associated with bone remodeling processes. By analyzing large amounts of data, we for the first time determined associations of signaling proteins that are process regulators characterizing new steps of bone remodeling in astronauts during the acute period of readaptation after landing.
Keywords:regulatory proteins of blood proteome biological processes bone remodeling astronauts
The authors express their sincere gratitude to the astronauts who took part in the study, the staff of the Gagarin Research & Test Cosmonaut Training Center for assistance in conducting the experiment, V. A. Ivanisenko, the head of the Laboratory of Computer-Assisted Proteomics of the Institute of Cytology and Genetics of the Russian Academy of Sciences for the opportunity to work with the ANDSystem program, and Prof. Christoph H. Borchers from the UVic-Genome BC Proteomics Center (University of Victoria, Columbia, Canada) for mass spectrometric analysis of samples.
The study was performed in the framework of the Basic Topics of the Russian Academy of Sciences 65.1 and 65.3 for 2013–2020.
COMPLIANCE WITH ETHICAL STANDARDS
Conflict of interests. The authors declare that they have no conflict of interest.
Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the principles of biomedical ethics formulated in the 1964 Helsinki Declaration and its later amendments and were approved by the Commission on Biomedical Ethics of the Institute of Biomedical Problems of the Russian Academy of Sciences (Moscow). Informed consent was obtained from all individual participants involved in the study.
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