Polymorphism of the vascular endothelial growth factor gene (VEGF) and aerobic performance in athletes
The subject of this study is the frequency distribution of alleles of the vascular endothelial growth factor gene (VEGF; the G-634C polymorphism) in athletes (n = 670) and in a control group (n = 1073) and the relationships of genotypes with aerobic performance in rowers (n = 90). Genetic typing was performed using the analysis of restriction fragment length polymorphism. The frequency of the VEGF C allele in the group of endurance athletes (n = 294) was significantly higher than in the control group and increased together with increasing sports qualification. In addition, a correlation of the VEGF C allele with a high aerobic performance of athletes (according to data on the maximal power and maximal oxygen consumption) and with a substantial contribution to the energy supply of aerobic metabolism (according to the values of maximal lactate content) has been found. It is inferred that the G-634C polymorphism of the VEGF gene is associated with physical performance of athletes and plays a key role in sports selection.
- 5.Brodal, P., Ingjer, F., and Hermansen, L., Capillary Supply of Skeletal Muscle Fibers in Untrained and Endurance-Trained Men, Am. J. Physiol. Heart Circ. Physiol., 1977, vol. 232, H705.Google Scholar
- 6.Gustafsson, T., Puntschart, A., Kaijser, L., Jansson, E., and Sundberg, C.J., Exercise-Induced Expression of Angiogenesis-Related Transcription and Growth Factors in Human Skeletal Muscle, Am. J. Physiol. Heart Circ. Physiol., 1999, vol. 276, p. 679.Google Scholar
- 7.Richardson, R.S., Wagner, H., Mudaliar, S.R., Saucedo, E., Henry, R., and Wagner P.D., Exercise Adaptation Attenuates VEGF Gene Expression in Human Skeletal Muscle, Am. J. Physiol. Heart Circ. Physiol., 2000, vol. 279, p. 772.Google Scholar
- 13.Bolla, M.K., Haddad, L., Humphries, S.E., et al., A Method of Determination of Hundreds of APOE Genotypes Utilizing Highly Simplified, Optimized Protocols and Restriction Digestion Analysis by Microtitre Array Diagonal Gel Electrophoresis (MADGE), Clin. Chem., 1995, vol. 41, p. 1599.PubMedGoogle Scholar