Advertisement

Theoretical Foundations of Chemical Engineering

, Volume 53, Issue 5, pp 939–944 | Cite as

Analysis of Extraction Chromatographic Separation of a Binary Mixture in a Series of Multistage Columns

  • A. E. KostanyanEmail author
  • M. M. Martynova
UNIT OPERATIONS AND EQUIPMENT OF CHEMICAL ENGINEERING
  • 1 Downloads

Abstract

Two processes of multistage extraction chromatographic separation of components (with and without recycling) are theoretically studied under various conditions of loading of a mixture to be separated to the apparatus. A mathematical description of the separation processes is presented. It is shown that the separation of components in the process with recycling requires an order of magnitude fewer equilibrium stages than separation in the process without recycling. Moreover, the productivity of the process with recycling, which is determined by the duration of loading to the apparatus, is an order of magnitude higher.

Keywords:

preparative liquid–liquid chromatography multistage extraction mathematical modeling of separation processes 

Notes

FUNDING

This work was supported by the Russian Foundation for Basic Research (project no. 18-33-00081 mol_a).

REFERENCES

  1. 1.
    Kostanyan, A.E., Erastov, A.A., Belova, V.V., and Khol’kin, A.I., New extraction–chromatography processes for the separation of organic and inorganic substances, Khim. Tekhnol., 2015, vol. 16, no. 4, pp. 239–245.Google Scholar
  2. 2.
    Belova, V.V., Combined extraction–chromatography processes for separation and purification of substances, Khim. Tekhnol., 2016, vol. 17, no. 12, pp. 554–559.Google Scholar
  3. 3.
    Maryutina, T.A., Spivakov, B.Ya., Shpigun, L.K., Pavlenko, I.V., and Zolotov, Yu.A., Preconcentration and separation of ortho- and pyrophosphate ions by countercurrent partition chromatography, Zh. Anal. Khim., 1990, vol. 45, no. 4, pp. 665–670.Google Scholar
  4. 4.
    Fedotov, P.S., Maryutina, T.A., Grebneva, O.N., Kuz’min, N.M., and Spivakov, B.Ya., Use of countercurrent partition chromatography for the preconcentration and separation of inorganic compounds: Group extraction of Zr, Hf, Nb, and Ta for their subsequent determination by inductively coupled plasma atomic emission spectrometry, J. Anal. Chem., 1997, vol. 52, no. 11, pp. 1034– 1038.Google Scholar
  5. 5.
    Chmutova, M.K., Maryutina, T.A., Spivakov, B.Ya., and Myasoedov, B.F., Separation of americium(III) and europium(III) in systems with neutral bidentate organophosphorus extractants by countercurrent partition chromatography, Radiokhimiya, 1992, no. 6, pp. 56–63.Google Scholar
  6. 6.
    Maryutina, T.A. and Ignatova, S.N., Countercurrent chromatography for the preconcentration and separation of inorganic compounds: Influence of physicochemical properties of two-phase liquid systems on the retention of the stationary phase, J. Anal. Chem., 1998, vol. 53, no. 8, pp. 740–745.Google Scholar
  7. 7.
    Friesen, J.B., McAlpine, J.B., Chen, S.-N., and Pauli, G.F., Countercurrent separation of natural products: An update, J. Nat. Prod., 2015, vol. 78, pp. 1765–1796.  https://doi.org/10.1021/np501065h CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Ignatova, S. and Sutherland, I., The 8th International Conference on Counter-Current Chromatography held at Brunel University, London, UK, July 23–25, 2014, J. Chromatogr. A, 2015, vol. 1425, pp. 1–7.  https://doi.org/10.1016/j.chroma.2015.10.096 CrossRefPubMedGoogle Scholar
  9. 9.
    Marchal, L., Legrand, J., and Foucault, A., Centrifugal partition chromatography: A survey of its history, and our recent advances in the field, Chem. Rec., 2003, vol. 3, no. 3, pp. 133–143.  https://doi.org/10.1002/tcr.10057 CrossRefPubMedGoogle Scholar
  10. 10.
    Ito, Y., Golden rules and pitfalls in selecting optimum conditions for high-speed counter-current chromatography, J. Chromatogr. A, 2005, vol. 1065, pp. 145–168.  https://doi.org/10.1016/j.chroma.2004.12.044 CrossRefPubMedGoogle Scholar
  11. 11.
    Morley, R. and Minceva, M., Trapping multiple dual mode centrifugal partition chromatography for the separation of intermediately-eluting components: Throughput maximization strategy, J. Chromatogr. A, 2017, vol. 1501, pp. 26–38.  https://doi.org/10.1016/j.chroma.2017.04.033 CrossRefPubMedGoogle Scholar
  12. 12.
    Kotland, A., Chollet, S., Autret, J.-M., Diard, C., Marchal, L., and Renault, J.-H., Modeling pH-zone refining countercurrent chromatography: A dynamic approach, J. Chromatogr. A, 2015, vol. 1391, pp. 80–87.  https://doi.org/10.1016/j.chroma.2015.03.005 CrossRefPubMedGoogle Scholar
  13. 13.
    Wang, Y., Zhang, L., Zhou, H., Guo, X., and Wu, S., K-targeted strategy for isolation of phenolic alkaloids of Nelumbo nucifera Gaertn by counter-current chromatography using lysine as a pH regulator, J. Chromatogr. A, 2017, vol. 1490, pp. 115–125.  https://doi.org/10.1016/j.chroma.2017.02.022 CrossRefPubMedGoogle Scholar
  14. 14.
    Peng, A., Hewitson, P., Ye, H., Zu, L., Garrard, I., Sutherland, I., Chen, L., and Ignatova, S., Sample injection strategy to increase throughput in counter-current chromatography: Case study of Honokiol purification, J. Chromatogr. A, 2016, vol. 1476, pp. 19–24.  https://doi.org/10.1016/j.chroma.2016.10.040 CrossRefPubMedGoogle Scholar
  15. 15.
    Boonloed, A., Weber, G.L., Ramzy, K.M., Dias, V.R., and Remcho, V.T., Centrifugal partition chromatography: A preparative tool for isolation and purification of xylindein from Chlorociboria aeruginosa, J. Chromatogr. A, 2016, vol. 1478, pp. 19–25.  https://doi.org/10.1016/j.chroma.2016.11.026 CrossRefPubMedGoogle Scholar
  16. 16.
    Kostanyan, A.E., Voshkin, A.A., Khol’kin, A.I., and Belova, V.V., RF Patent 2403949, 2010.Google Scholar
  17. 17.
    Kostanyan, A.E., Voshkin, A.A., and Kodin, N.V., Controlled-cycle pulsed liquid–liquid chromatography. A modified version of Craig’s counter-current distribution, J. Chromatogr. A, 2011, vol. 1218, no. 36, pp. 6135–6143.  https://doi.org/10.1016/j.chroma.2010.12.103 CrossRefPubMedGoogle Scholar
  18. 18.
    Porter, R.S. and Johnson, J.F., Circular gas chromatograph, Nature, 1959, vol. 183, pp. 391–392.  https://doi.org/10.1038/183391a0 CrossRefGoogle Scholar
  19. 19.
    Xie, J., Deng, J., Tan, F., and Su, J., Separation and purification of echinacoside from Penstemon barbatus (Can.) Roth by recycling high-speed counter-current chromatography, J. Chromatogr. B, 2010, vol. 878, pp. 2665–2668.  https://doi.org/10.1016/j.jchromb.2010.07.023 CrossRefGoogle Scholar
  20. 20.
    Han, Q.B., Song, J.Z., Qiao, C.F., Wong, L., and Xu, H.X., Preparative separation of gambogic acid and its C-2 epimer using recycling high-speed counter-current chromatography, J. Chromatogr. A, 2006, vol. 1127, pp. 298–301.  https://doi.org/10.1016/j.chroma.2006.07.044 CrossRefPubMedGoogle Scholar
  21. 21.
    Meng, J., Yang, Z., Liang, J., Zhou, H., and Wu, S., Multi-channel recycling counter-current chromatography for natural product isolation: Tanshinones as examples, J. Chromatogr. A, 2014, vol. 1327, pp. 27–38.  https://doi.org/10.1016/j.chroma.2013.12.069 CrossRefPubMedGoogle Scholar
  22. 22.
    Kostanyan, A.E. and Erastov, A.A., Theoretical study of closed-loop recycling liquid-liquid chromatography and experimental verification of the theory, J. Chromatogr. A, 2016, vol. 1462, pp. 55–62.  https://doi.org/10.1016/j.chroma.2016.07.079 CrossRefPubMedGoogle Scholar
  23. 23.
    Kostanyan, A.E., Simple equations to simulate closed-loop recycling liquid–liquid chromatography: Ideal and non-ideal recycling models, J. Chromatogr. A, 2015, vol. 1423, pp. 71–78.  https://doi.org/10.1016/j.chroma.2015.10.052 CrossRefPubMedGoogle Scholar
  24. 24.
    Kostanyan, A.E., Modeling of preparative closed-loop recycling liquid-liquid chromatography with specified duration of sample loading, J. Chromatogr. A, 2016, vol. 1471, pp. 94–101.  https://doi.org/10.1016/j.chroma.2016.10.012 CrossRefPubMedGoogle Scholar
  25. 25.
    Kostanyan, A.E., Theoretical study of separation and concentration of solutes by closed-loop recycling liquid-liquid chromatography with multiple sample injection, J. Chromatogr. A, 2017, vol. 1506, pp. 82–92.  https://doi.org/10.1016/j.chroma.2017.05.042 CrossRefPubMedGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of SciencesMoscowRussia

Personalised recommendations