Aqueous Solubility Enhancement and Thermodynamic Aggregation Behavior of Resveratrol Using an Eco-Friendly Hydrotropic Phenomenon
Resveratrol, a stilbenoid polyphenol compound found in the skin and seeds of black grapes, which is supposed to have biological activity as an anti-inflammatory, anti-tumor, and anti-aging agent. Low oral bioavailability of resveratrol is determined by its low solubility in water. To overcome this, a biocompatible solubilization method is used to intensify the solubility of resveratrol. Hydrotropes (solubilizing agents) such as sodium caprylate, and sodium benzoate under a wide range of concentrations (0‒3 mol/L) and temperature (303–333 K) were used to study the aqueous solubility of resveratrol. It is observed that the solubility of resveratrol is enhanced by 16 times in the presence of sodium caprylate as hydrotrope. Thermodynamic properties like entropy, Gibbs free energy, and enthalpy were determined, and the solubilization process was found to be entropy-driven.
Keywords:resveratrol hydrotrope solubility thermodynamic aggregation behavior
CONFLICT OF INTEREST
The authors declare that they have no conflict of interest.
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