Journal of Structural Chemistry

, Volume 60, Issue 5, pp 838–844 | Cite as

Three New Metal-Organic Coordination Complexes: Crystal Structures and Anticancer Activity in Multiple Myeloma

  • Y. -Y. Yang
  • J. -H. Yang
  • D. WangEmail author


Three new metal-organic coordination complexes, namely [Cu(4,4′-bipy)2(NCS)2]n (I), [Cu(HCOO)2(4,4′—bipy)] (II), and [Cu(2,2′-bipy)2]2(V6O17) (III) (4,4′-bipy and 2,2′-bipy = 4,4′-bipyridine and 2,2′-bipyridine, respectively) are successfully prepared by using two similar pyridine ligands with different orientations of N atoms under different reaction conditions (slow volatilization for I, solvothermal for II and III). Their structures and compositions are characterized by both single crystal X-ray diffraction and elemental analysis. Additionally, the newly synthesized compounds are evaluated to identify the molecular characteristics contributing to their cytotoxicity. They are tested against three human multiple myeloma cells (NCI-H929, MM1S, and MM1R) with the MTT assay.


metal-organic coordination complexes single crystal human tumor cells 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    R. P. Perez, T. C. Hamilton, R. F. Ozols, and R. C. Young. Cancer, 1993, 71, 1571.CrossRefGoogle Scholar
  2. 2.
    E. Won and C. M. Giandomenico. Chem. Rev., 1999, 99, 2451.CrossRefGoogle Scholar
  3. 3.
    L. Rubbia-Brandt. Ann. Oncol., 2004, 15, 460.CrossRefGoogle Scholar
  4. 4.
    D. Senthil Raja, E. Ramachandran, N. S. P. Bhuvanesh, and K. Natarajan. Eur. J. Med. Chem., 2013, 64, 148.CrossRefGoogle Scholar
  5. 5.
    B. Cvek, V. Milacic, J. Taraba, and Q. P. Dou. J. Med. Chem., 2008, 51, 6256.CrossRefGoogle Scholar
  6. 6.
    C. J. Anderson and R. Ferdani. Cancer Biother. Radiopharm., 2009, 24, 379.CrossRefGoogle Scholar
  7. 7.
    M. T. Tarafder, K. T. Jin, K. A. Crouse, A. Ali, B. Yamin, and H. K. Fun. Polyhedron, 2002, 21, 2547.CrossRefGoogle Scholar
  8. 8.
    Y. Feng, H. Fan, Z. Zhong, H. Wang, and D. Qiu. Inorg. Chem., 2016, 55, 11987.CrossRefGoogle Scholar
  9. 9.
    Y. Feng, M. Li, H. Fan, Q. Huang, D. Qiu, and H. Shi. Dalton Trans., 2015, 44, 894.CrossRefGoogle Scholar
  10. 10.
    C. W. Duan, L. X. Hu, and J. L. Ma. J. Mater. Chem. A, 2018, 6, 6309.CrossRefGoogle Scholar
  11. 11.
    D. J. Collins and H. C. Zhou. J. Mater. Chem., 2007, 17, 3154.CrossRefGoogle Scholar
  12. 12.
    D. Feng, Z. Y. Gu, J. R. Li, H. L. Jiang, Z. Wei, and H. C. Zhou. Angew. Chemie-Int. Ed., 2012, 51, 10307.CrossRefGoogle Scholar
  13. 13.
    A. M. Spokoyny, D. Kim, A. Sumrein, and C. A. Mirkin. Chem. Soc. Rev. 2009, 38, 1218.CrossRefGoogle Scholar
  14. 14.
    R. Koner and I. Goldberg. Acta Crystallogr. Sect. C, Cryst. Struct. Commun., 2009, 65, m185.CrossRefGoogle Scholar
  15. 15.
    J. W. Cui, X. B. Cui, H. H. Yu, J. Q. Xu, and S. H. Wang. Acta Crystallogr. Sect. E, Struct. Rep. Online, 2010, 66, m568.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Department of Hematology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanP. R. China

Personalised recommendations