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Journal of Structural Chemistry

, Volume 60, Issue 5, pp 838–844 | Cite as

Three New Metal-Organic Coordination Complexes: Crystal Structures and Anticancer Activity in Multiple Myeloma

  • Y. -Y. Yang
  • J. -H. Yang
  • D. WangEmail author
Article
  • 1 Downloads

Abstract

Three new metal-organic coordination complexes, namely [Cu(4,4′-bipy)2(NCS)2]n (I), [Cu(HCOO)2(4,4′—bipy)] (II), and [Cu(2,2′-bipy)2]2(V6O17) (III) (4,4′-bipy and 2,2′-bipy = 4,4′-bipyridine and 2,2′-bipyridine, respectively) are successfully prepared by using two similar pyridine ligands with different orientations of N atoms under different reaction conditions (slow volatilization for I, solvothermal for II and III). Their structures and compositions are characterized by both single crystal X-ray diffraction and elemental analysis. Additionally, the newly synthesized compounds are evaluated to identify the molecular characteristics contributing to their cytotoxicity. They are tested against three human multiple myeloma cells (NCI-H929, MM1S, and MM1R) with the MTT assay.

Keywords

metal-organic coordination complexes single crystal human tumor cells 

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Department of Hematology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanP. R. China

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