Dipeptides Beta- L-Aspartyl-Serine and Beta-L-Aspartyl-Proline in Memory Regulation in the Honeybee

  • N. I. Chalisova
  • T. G. ZachepiloEmail author
  • N. G. Kamyshev
  • N. G. Lopatina
Comparative and Ontogenic Physiology


We report a comparative analysis of the effect of alpha- and beta- isomers of the dipeptides aspartyl-serine and aspartyl-proline on the ability of honeybees to retain the conditioned food reflex to olfactory cues in their short-term/long-term memory. Stimulatory/inhibitory effects of the alpha-dipeptides on memory processes are confined to the concentration range of 10-6–10-8 M. In contrast, beta-dipeptides exert stimulatory/inhibitory effects on memory not only within the same range but also at ultra-low (pico- and femtomolar) concentrations. At concentrations of 10-9–10-11 M, beta-dipeptides have no effect on the characteristics under study (“silence zone”). Thus, we revealed fundamental differences in the effects of alpha- and beta- dipeptide isomers on the memory regulation.


alpha and beta dipeptides memory honeybee 



short-term memory


long-term memory










small neuropeptide F


pheromone biosynthesis activation neuropeptide


amide-phenylalanine-methi-onyl- arginyl-phenylalanine amide


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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • N. I. Chalisova
    • 1
  • T. G. Zachepilo
    • 1
    Email author
  • N. G. Kamyshev
    • 1
  • N. G. Lopatina
    • 1
  1. 1.Pavlov Institute of PhysiologyRussian Academy of SciencesSt. PetersburgRussia

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