Reduction of Acridine and 9-Chloroacridine with Red Phosphorus in the KOH/DMSO System
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Acridine reacts with red phosphorus in the KOH/DMSO(H2O) system on heating (100°C, 3 h) to give 9,10-dihydroacridine regioselectively in quantitative yield. Under similar conditions, 9-chloroacridine reacts with Pred/KOH/DMSO(H2O) system to afford 9,10-dihydroacridine and acridone in 51 and 40% yield, respectively.
This work was performed using equipment of the Shared Facility Center, Baikal Analytical Center, Siberian Branch, Russian Academy of Sciences.
This work was supported by the Russian Foundation for Basic Research (project no. 17–03–00739).
- 4.Fieser, L. and Fieser, J.F., Reagents for Organic Synthesis, Wiley, 1974, vol. 4, Translated under the title Reagenty dlya organicheskogo sinteza, Moscow: Mir, 1978.Google Scholar
- 6.Trofimov, B.A. and Gusarova, N.K., Mendeleev Commun., 2009, no. 6, pp. 295–302.Google Scholar
- 12.Shahid, M.D., US Patent 6525146, 2003.Google Scholar