Doklady Chemistry

, Volume 487, Issue 1, pp 173–176 | Cite as

Peptide Derivatives of Some Physiologically Active Substances

  • V. P. ShevchenkoEmail author
  • L. A. Andreeva
  • I. Yu. Nagaev
  • N. F. Myasoedov


The synthesis of Boc-Gly-Pro-Dox, Boc-Gly-Pro-DOPA, and Boc-Gly-Pro-Srt and their deuterated analogues was carried out. The condensation is accompanied by side reactions, which could be minimized by optimizing the reaction conditions. The most versatile approach to the synthesis of Boc-Gly-Pro-Dox, Boc-Gly-Pro-DOPA, and Boc-Gly-Pro-Srt and their deuterated analogues is condensation of Boc-Gly-Pro or Boc-Gly-[2H]Pro with the amino groups of dopamine, serotonin, and doxorubicin. For the introduction of hydrogen isotopes into ΔPro, hydrogenation of its aqueous solution followed by condensation of the reduced proline with Boc-GlyOSu is recommended. Mass spectrometry was used to determine the content of isotopomers in the deuterated products.



This work was partially supported by the Basic Research Program of the Presidium of the RAS “Basic Research for Biomedical Technologies.”


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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • V. P. Shevchenko
    • 1
    Email author
  • L. A. Andreeva
    • 1
  • I. Yu. Nagaev
    • 1
  • N. F. Myasoedov
    • 1
  1. 1.Institute of Molecular Genetics, Russian Academy of SciencesMoscowRussia

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