Physical Fatigue and Morphofunctional State of the Myocardium in Experimental Chronic Stress
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The relationship between the development of skeletal muscle fatigue of a specific type in male Wistar rats and morphofunctional alterations in the myocardium in the posttraumatic stress disorder (PTSD) model has been investigated for the first time. The aggravation of oxidative stress in the cardiomyocytes and the related transformation of the cell structural components and the depletion of energy reserves in PTSD has been identified as one of the main factors that accelerate the onset of musculoskeletal fatigue.
This study was performed in the framework of the basic part of State Contract no. 17.7255.2017/8.9 with the Ministry of Education and Science of the Russian Federation and the State Contract with the Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences (topic no. AAAA-A18-118020590108-7).
COMPLIANCE WITH ETHICAL STANDARDS
Conflict of interests. The authors declare that they have no conflict of interest.
Statement on the welfare of animals. All experimental procedures were approved by the local ethical committee and implemented according to the EC Declaration on handling laboratory animals (2010).
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