Advertisement

Doklady Biological Sciences

, Volume 485, Issue 1, pp 27–29 | Cite as

Mechanisms of Blood Flow Regulation in the Skin during Stimulation of the Spinal Cord in Humans

  • G. I. LobovEmail author
  • Yu. P. Gerasimenko
  • T. R. Moshonkina
PHYSIOLOGY
  • 11 Downloads

Abstract

Changes in the blood flow in the shin skin were observed by laser Doppler flowmetry after transcutaneous electrical spinal cord stimulation (TSCS) by subthreshold bipolar pulses with a frequency of 30 Hz in 12 healthy subjects. It was found that TSCS in the area of the T11 and L1 vertebrae led to a significant increase in skin blood flow. The microcirculation rate increased by more than 85% relative to the baseline at a stimulus intensity of 90% of the motor threshold. Cutaneous blood flow activization by TSCS is implemented mainly through the antidromic stimulation of sensory nerve fibers. Nitric oxide (NO) is an important mediator that contributes to vasodilation and increase in cutaneous blood flow upon TSCS. NO is predominantly of endothelial origin.

Notes

ACKNOWLEDGMENTS

This study was supported by the Russian Foundation for Basic Research (project no. 16-29-08277) and Program for Basic Research of the Presidium of the Russian Academy of Sciences no. 1.42.

COMPLIANCE WITH ETHICAL STANDARDS

Conflict of interests. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

REFERENCES

  1. 1.
    Grishin, A.A., Moshonkina, T.R., Solopova, I.A., Gorodnichev, R.M., and Gerasimenko, Yu.P., Med. Tekh., 2016, no. 5, pp. 8–11.Google Scholar
  2. 2.
    Krupatkin, A.I. and Sidorov, V.V., Funktsional’naya diagnostika sostoyaniya mikrotsirkulyatorno-tkanevykh system: Rukovodstvo dlya vrachei (Functional Diagnosis of the Condition of Microcirculatory–Tissue Systems: A Physician’s Guide), Moscow: Librokom, 2013.Google Scholar
  3. 3.
    Lobov, G.I., Shcherbakova, N.A., Gorodnichev, R.M., Grishin, A.A., Gerasimenko, Yu.P., and Moshonki-na, T.R., Hum. Physiol., 2017, vol. 43, no. 5, pp. 518–523.CrossRefGoogle Scholar
  4. 4.
    van Beek, M., van Kleef, M., Linderoth, B., et al., Eur. J. Pain, 2017, vol. 21, no. 5, pp. 795–803.CrossRefGoogle Scholar
  5. 5.
    Bernjak, A., Cui, J., Iwase, S., et al., J. Physiol., 2012, vol. 590, no. 2, pp. 363–375.CrossRefGoogle Scholar
  6. 6.
    Carter, S.J. and Hodges, G.J., Exp. Physiol., 2011, vol. 96, no. 11, pp. 1208–1217.CrossRefGoogle Scholar
  7. 7.
    Charkoudian, N., J. Appl. Physiol., 2010, vol. 109, no. 4, pp. 1221–1228.CrossRefGoogle Scholar
  8. 8.
    Gerasimenko, Y., Gorodnichev, R., Moshonkina, T., Sayenko, D., and Gad, P., Ann. Phys. Rehabil. Med., 2015, vol. 58, no. 4, pp. 225–231.CrossRefGoogle Scholar
  9. 9.
    Gerasimenko, Y., Gorodnichev, R., Puhov, A., Moshonkina, T., Savochin, A., Selionov, V., Roy, R.R., Lu, D.C., and Edgerton, V.R., J. Neurophysiol., 2015, vol. 113, no. 3, pp. 834–842.CrossRefGoogle Scholar
  10. 10.
    Harkema, S., Gerasimenko, Y., Hodes, J., et al., Lancet, 2011, vol. 377, no. 9781, pp. 1938–1947.CrossRefGoogle Scholar
  11. 11.
    Hodges, G.J., Traeger, J.A., Tang, T., et al., Am. J. Physiol. Heart. Circ. Physiol., 2007, vol. 293, no. 1, pp. 784–789.CrossRefGoogle Scholar
  12. 12.
    Naoum, J.J. and Arbid, E.J., Methodist Debakey Cardiovasc. J., 2013, vol. 9, no. 2, pp. 99–102.CrossRefGoogle Scholar
  13. 13.
    Pedrini, L. and Magnoni, F., Interact. Cardiovasc. Thorac. Surg., 2007, vol. 6, no. 4, pp. 495–500.CrossRefGoogle Scholar
  14. 14.
    Sayenko, D.G., Atkinson, D.A., Floyd, T.C., et al., Neurosci. Lett., 2015, vol. 609, pp. 229–234.CrossRefGoogle Scholar
  15. 15.
    Wu, M., Komori, N., Qin, C., et al., Brain Res., 2007, vol. 1156, pp. 80–92.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • G. I. Lobov
    • 1
    Email author
  • Yu. P. Gerasimenko
    • 1
  • T. R. Moshonkina
    • 1
  1. 1.Pavlov Institute of Physiology, Russian Academy of SciencesSt. PetersburgRussia

Personalised recommendations