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Biophysics

, Volume 64, Issue 1, pp 89–94 | Cite as

The Biological Effect of Dinitrosyl Iron Complexes with Glutathione upon Nitric Oxide Hyperproduction Induced by Endotoxin Shock

  • A. A. TimoshinEmail author
  • V. L. Lakomkin
  • A. A. Abramov
  • A. F. Vanin
  • E. K. Ruuge
COMPLEX SYSTEMS BIOPHYSICS
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Abstract—The objective of this work was to study the biological effect of dinitrosyl iron complexes (DNICs) with the glutathione ligand (GSH−DNICs) as a stabilized form of nitric oxide in a rat model of nitric oxide hyperproduction induced by inflammation. Administration of GSH−DNICs in endotoxin shock did not increase the total nitric oxide levels in rat organs, but exerted a protective effect by suppressing nitric oxide hyperproduction in the liver and led to an accumulation of the complexes with protein ligands in the kidney.

Keywords: antioxidant inflammation dinitrosyl iron complexes nitric oxide spin trap electron paramagnetic resonance 

Notes

FUNDING

This work was supported by the Russian Foundation for Basic Research (project no. 18-015-00027).

COMPLIANCE WITH ETHICAL STANDARDS

Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Copyright information

© Pleiades Publishing, Inc. 2019

Authors and Affiliations

  • A. A. Timoshin
    • 1
    Email author
  • V. L. Lakomkin
    • 1
  • A. A. Abramov
    • 1
  • A. F. Vanin
    • 2
  • E. K. Ruuge
    • 1
  1. 1.National Medical Research Center for Cardiology, Ministry of Health of the Russian FederationMoscowRussia
  2. 2.Semenov Institute of Chemical Physics, Russian Academy of SciencesMoscowRussia

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