Biochemistry (Moscow)

, Volume 84, Issue 7, pp 773–781 | Cite as

MUC1 in Cancer Immunotherapy — New Hope or Phantom Menace?

  • M. S. SyrkinaEmail author
  • M. A. RubtsovEmail author


Understanding of the functioning of MUC1 (human mucin) has advanced significantly over 40 years of its investigation. The anti-adhesive properties of the extracellular domain, which were the main focus of early studies initially explaining overexpression of MUC1 in progressing oncological diseases, were gradually put on the back burner. Researchers became more interested in its regulatory and signaling functions in cells rather in its anti-adhesive properties. The found the ability of MUC1 for signal transduction, and its ability to participate in cell metabolism opened new possibilities for improved control over cancer cells in addition to just attracting antigens of the immune system to a target. Nevertheless, there are issues in the functioning of MUC1 that raise doubts about its effectiveness in cancer immunotherapy.


mucin MUC1 immunotherapy glycosylation immunosuppression tandem repeats CAR-T 



antigen-presenting cell


T-lymphocyte carrying chimeric antigen receptor


major histocompatibility complex


human mucin


C-terminal (cytoplasmic) MUC1 subunit


N-terminal (extracellular) MUC1 subunit


T-cell receptor


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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  1. 1.Department of BiologyLomonosov Moscow State UniversityMoscowRussia
  2. 2.Laboratoire Franco-Russe de Recherches en OncologieLomonosov Moscow State UniversityMoscowRussia
  3. 3.Sechenov First Moscow State Medical University (Sechenov University)MoscowRussia

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