Biochemistry (Moscow)

, Volume 84, Issue 3, pp 205–219 | Cite as

KH-Domain Poly(C)-Binding Proteins as Versatile Regulators of Multiple Biological Processes

  • I. B. NazarovEmail author
  • E. I. Bakhmet
  • A. N. Tomilin


Five known members of the family of KH-domain poly(C)-binding proteins (Pcbp1-4, hnRNP-K) have an unusually broad spectrum of cellular functions that include regulation of gene transcription, regulation of pre-mRNA processing, splicing, mRNA stability, translational silencing and enhancement, the control of iron turnover, and many others. Mechanistically, these proteins act via nucleic acid binding and protein–protein interactions. Through performing these multiple tasks, the KH-domain poly(C)-binding family members are involved in a wide variety of biological processes such as embryonic development, cell differentiation, and cancer. Deregulation of KH-domain protein expression is frequently associated with severe developmental defects and neoplasia. This review summarizes progress in studies of the KH-domain proteins made over past two decades. The review also reports our recent finding implying an involvement of the KH-factor Pcbp1 into control of transition from naive to primed pluripotency cell state.


Pcbp1-4 hnRNP-K gene expression cell cycle cancer embryonic development pluripotent stem cells 



cluster of differentiation 43




cell division cycle 27


cyclin dependent kinase 2


chromatin immunoprecipitation


genome editing technology


differentiation control element


epithelial–mesenchymal transition


embryonic stem cells


G-protein-associated receptor


hypoxia inducible factor α


heterogenous nuclear ribonucleoprotein K


internal ribosome entry site

KH-proteins (or KH-domain proteins)

KH-domain poly(C)-binding proteins




μ-opioid receptor


cyclin-dependent kinase inhibitor 1A (CDKN1A)


tumor antigen p53


Pcbp2, Pcbp3, Pcbp4, Poly(C)-binding proteins 1,2,3,4


polo-like kinase 1


DNA polymerase η


programmed ribosomal frameshifting


hematopoietic transcription factor PU.1


small interfering RNA


small nuclear ribonuclear protein


THAP domain containing protein


untranslated region


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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • I. B. Nazarov
    • 1
    Email author
  • E. I. Bakhmet
    • 1
  • A. N. Tomilin
    • 1
  1. 1.Institute of CytologyRussian Academy of SciencesSt. PetersburgRussia

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