Advertisement

Applied Biochemistry and Microbiology

, Volume 55, Issue 4, pp 355–359 | Cite as

Analysis of Serum Albumin Isoforms Belonging to Membranotropic Homeostatic Tissue-Specific Bioregulators Isolated from Different Mammalian Tissues

  • A. P. Ilyina
  • E. V. Sidorsky
  • P. A. ElistratovEmail author
  • V. M. Chekova
  • V. P. YamskovaEmail author
  • I. A. Yamskov
Article
  • 6 Downloads

Abstract

Membranotropic homeostatic tissue-specific bioregulators (MHTBs) isolated from various tissues of cattle (Bos taurus) and rats (Rattus norvegicus) basically comprise peptide-protein complexes consisting of low-molecular polypeptides (1–6 kDa) and serum albumin represented in NCBI databases by three isoforms for each of the species: gi|1351907, gi|367460260, gi|74267962 and gi|124028612, gi|158138568, and gi|55628, respectively. The sites of amino acid substitutions in the primary sequence of these albumins are determined to be located in the second and third domains of the albumin molecules. The polypeptides in the MHTB composition are the proteolysis products of enzymes and adhesive proteins.

Keywords:

bioregulators peptide-protein complex albumin 

Notes

REFERENCES

  1. 1.
    Yamskova, V.P., Krasnov, M.S., and Yamskov, I.A., Novye eksperimental’nye i teoreticheskie aspekty v bioregulyatsii. Mekhanizm deistviya membranotropnykh gomeostaticheskikh bioregulyatorov (New Experimental and Theoretical Aspects in Bioregulation. The Mechanism of Action of Membranotropic Homeostatic Bioregulators), Starbucken: Lambert Academic Publishing, 2012.Google Scholar
  2. 2.
    Yamskova, V.P., Skripnikova, V.S., Molyavka, A.A., Il’ina, A.P., Krasnov, M.S., Margasyuk, D.V., Borisenko, A.V., Berezin, B.B., Kuznetsova, E.S., Buryak, A.K., and Yamskov, I.A., Biochemistry (Moscow), 2009, vol. 74, no. 9, pp. 971–978.Google Scholar
  3. 3.
    Yamskova, V.P., Rybakova, E.Yu., Vinogradov, A.A., Vecherkin, V.V., and Yamskov, I.A., Appl. Biochem. Microbiol., 2004, vol. 40, no. 4, pp. 345–350.CrossRefGoogle Scholar
  4. 4.
    Maltsev, D.I., Yamskova, V.P., Il’ina, A.P., Beresin, B.B., and Yamskov, I.A., Appl. Biochem. Microbiol., 2016, vol. 52, no. 3, pp. 342–346.CrossRefGoogle Scholar
  5. 5.
    Il’ina, A.P., Kulikova, O.G., Maltsev, D.I., Krasnov, M.S., Rybakova, E.Yu., Skripnikova, V.S., Kuznetsova, E.S., Buryak, A.K., Yamskova, V.P., and Yamskov, I.A., Appl. Biochem. Microbiol., 2011, vol. 47, no. 2, pp. 118–122.CrossRefGoogle Scholar
  6. 6.
    Kragh-Hansen, U., Minchiotti, L., Galliano, M., and Peters, T., Biochim. Biophys. Acta, 2013, vol. 1830, no. 12, pp. 5405–5417.CrossRefGoogle Scholar
  7. 7.
    Dawson, R., Elliott, D., Elliott, W., and Jones, K., Data for Biochemical Research, 3rd ed., Oxford: Clarendon, 1986.Google Scholar
  8. 8.
    Yamskova, V.P. and Reznikova, M.M., Zh. Obshch. Biol., 1991, vol. 52, no. 2, pp. 181–191.Google Scholar
  9. 9.
    Edman, P., Arch. Biochem., 1949, vol. 22, no. 3, pp. 475–483.Google Scholar
  10. 10.
    Laemmli, U.K., Nature, 1970, vol. 227, no. 5259, pp. 680–685.CrossRefGoogle Scholar
  11. 11.
    Il'ina, A.P., Molyavka, A.A., Yamskova, V.P., Buryak, A.K., and Yamskov, I.A., Appl. Biochem. Microbiol., 2014, vol. 50, no. 4, pp. 398–403.CrossRefGoogle Scholar
  12. 12.
    Yamskova, V.P., Krasnov, M.S., and Yamskov, I.A., Nanorazmernye bioregulyatory tkanei glaza mlekopitayushchikh kak osnova dlya farmakologicheskikh preparatov novogo pokoleniya (Nanoscale Bioregulators of Mammalian Eye Tissues as a Basis for New-Generation Pharmaceuticals), Moscow: Maks Press, 2009.Google Scholar
  13. 13.
    Yamskova, V.P., Nechaeva, N.V., Tumanova, N.B., Yurovitskii, Yu.G., Novikova, T.E., Fateeva, V.I., and Gvazava, I.G., Izv. Ross. Akad. Nauk, Ser. Biol., 1994, no. 2, pp. 190–196.Google Scholar
  14. 14.
    Direktiva 2010/63/EU Evropeiskogo parlamenta i soveta evropeiskogo soyuza po okhrane zhivotnykh, ispol’zuemykh v nauchnykh tselyakh (Directive 2010/63 /EU of the European Parliament and the Council of the European Union on the Protection of Animals Used for Scientific Purposes), St. Petersburg: Rus-LASA NP Ob’’edinenie spetsialistov po rabote s laboratornymi zhivotnymi, 2010.Google Scholar

Copyright information

© Pleiades Publishing, Inc. 2019

Authors and Affiliations

  • A. P. Ilyina
    • 1
  • E. V. Sidorsky
    • 1
  • P. A. Elistratov
    • 2
    Email author
  • V. M. Chekova
    • 2
  • V. P. Yamskova
    • 2
    Email author
  • I. A. Yamskov
    • 1
  1. 1.Nesmeyanov Institute of Organoelement Compounds, Russian Academy of ScienceMoscowRussia
  2. 2.Institute of Bioregulation Problems LLCMoscowRussia

Personalised recommendations