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Applied Biochemistry and Microbiology

, Volume 55, Issue 1, pp 21–24 | Cite as

Modified Antiproteinase Hemosorbent

  • I. L. ValuevEmail author
  • L. I. Valuev
  • L. V. Vanchugova
  • I. V. Obydennova
Article
  • 9 Downloads

Abstract

A method to increase the thromboresistance of the biospecific antiproteinase hemosorbent was suggested based on simultaneous immobilization of duck egg ovomucoid and blood anticoagulant—heparin or hirudin—in the bulk of polyacrylamide hydrogel. It was demonstrated that modification of the hemosorbent with hirudin resulted in a significant increase of its compatibility with blood with simultaneous preservation of high capacity with regards to serine proteinases.

Keywords:

hemosorbent duck ovomucoid hirudin heparin 

Notes

ACKNOWLEDGMENTS

This work was financially supported by the Federal Agency of Scientific Organization of Russia (theme 3, scientific direction 45, state registration АААА-А18-118011990207-1).

COMPLIANCE WITH ETHICAL STANDARDS

The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Copyright information

© Pleiades Publishing, Inc. 2019

Authors and Affiliations

  • I. L. Valuev
    • 1
    Email author
  • L. I. Valuev
    • 1
  • L. V. Vanchugova
    • 1
  • I. V. Obydennova
    • 1
  1. 1.Topchiev Institute of Petrochemical Synthesis, Russian Academy of SciencesMoscowRussia

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