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Applied Biochemistry and Microbiology

, Volume 54, Issue 5, pp 522–527 | Cite as

Carbohydrate Specificity of Antibodies against Phytopathogenic Fungi of the Aspergillus Genus

  • V. B. Krylov
  • M. I. Petruk
  • N. I. Glushko
  • E. V. Khaldeeva
  • V. L. Mokeeva
  • E. N. Bilanenko
  • Y. S. Lebedin
  • S. A. Eremin
  • N. E. Nifantiev
Article

Abstract

Brush rabbits were immunized with injections prepared from the fungi Aspergillus fumigatus, Aspergillus niger, and Aspergillus repens. A library of synthetic biotinylated oligosaccharides containing the key fragments of antigenic polysaccharides of the fungal cell wall—galctomannan, α- and β-glucans, mannan, and chitin—was used to analyze carbohydrate specificity. The anticarbohydrate antibodies obtained from animals immunized with preparations from A. fumigatus and A. repens predominantly recognized epitopes containing galactofuranoside residues, while the majority of the antibodies against A. niger bound the chitooligosaccharide ligand. These results are the basis for the identification of specific markers required for the development of immunoenzyme test systems.

Keywords

Aspergillus fumigatus Aspergillus niger Aspergillus repens aspergillosis antigen antibody 

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References

  1. 1.
    Samson, R.A., Visagie, C.M., Houbraken, J., Hong, S.B., Hubka, V., Klaassen, C.H.W., Perrone, G., Seifert, K.A., Susca, A., Tanney, J.B., Varga, J., Kocsube, S., Szigeti, G., Yaguchi, T., and Frisvad, J.C., Stud. Mycol., 2014, vol. 78, pp. 141–173.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Antropova, A.B., Mokeeva, V.L., Bilanenko, E.N., Chekunova, L.N., Zheltikova, T.M., and Petrova-Nikitina, A.D., Mikol. Fitopatol., 2004, vol. 38, no. 5, pp. 32–41.Google Scholar
  3. 3.
    Domsch, K.H., Gams, W., and Anderson, T-H., Compendium of Soil Fungi, Gams, W., Ed., Koeltz Sci. Books Publ., 2007.Google Scholar
  4. 4.
    Klich, M.A., Mol. Plant Pathol., 2007, vol. 8, no. 6, pp. 713–722.CrossRefPubMedGoogle Scholar
  5. 5.
    Guarro, J., Gene, J., and Figueras, M.J., Atlas of Clinical Fungi, Centraalbureau voor Schimmelcultures, Universitat Rovira i Virgili, 2000, 2nd ed.Google Scholar
  6. 6.
    Latgé, J.P., Mol. Microbiol., 2007, vol. 66, no. 2, pp. 279–290.CrossRefPubMedGoogle Scholar
  7. 7.
    Bongomin, F., Gago, S., Oladele, R.O., and Denning, D.W., J. Fungi, 2017, vol. 3, no. 4, p. 57.CrossRefGoogle Scholar
  8. 8.
    Klimko, N., Kozlova, Y., Khostelidi, S., Shadrivova, O., Borzova, Y., Burygina, E., Vasilieva, N., and Denning, D.W., Mycoses, 2015, vol. 58, no. 5, pp. 58–62.CrossRefPubMedGoogle Scholar
  9. 9.
    Groll, A.H., Shah, P.M., Mentzel, C., Schneider, M., Just-Nuebling, G., and Huebner, K., J. Infect., 1996, vol. 33, no. 1, pp. 23–32.CrossRefPubMedGoogle Scholar
  10. 10.
    Kohno, S., Clin. Infect. Dis., 2008, vol. 47, no. 9, pp. 1185–1187.CrossRefPubMedGoogle Scholar
  11. 11.
    Walsh, T.J., Anaissie, E.J., Denning, D.W., Herbrecht, R., Kontoyiannis, D.P., Marr, K.A., and Patterson, T.F., Clin. Infect. Dis., 2008, vol. 46, no. 3, pp. 327–360.CrossRefPubMedGoogle Scholar
  12. 12.
    Schuster, E., Dunn-Coleman, N., Frisvad, J.C., and Van Dijck, P., Appl. Microbiol. Biotechnol., 2002, vol. 59, nos. (4–5), pp. 426–435.PubMedGoogle Scholar
  13. 13.
    Raper, K.B. and Fennell, D.I., The Genus Aspergillus, Baltimore: Williams and Wilkins, 1965.Google Scholar
  14. 14.
    de Vries, R.P., Riley, R., Wiebenga, A., Aguilar-Osorio, G., et al., Genome Biol., 2017, vol. 18, no. 28. doi 10.1186/s13059-017-1151-0Google Scholar
  15. 15.
    White, P.L., Barnes, R.A., Springer, J., Klingspor, L., Cuenca-Estrella, M., and Morton, C.O., J. Clin. Microbiol., 2015, vol. 53, no. 9, pp. 2832–2837.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    McCarthy, M.W. and Walsh, T.J., Exp. Rev. Resp. Med., 2017, vol. 11, no. 9, pp. 739–748.CrossRefGoogle Scholar
  17. 17.
    Stynen, D., Goris, A., Sarfati, J., and Latge, J.P., J. Clin. Microbiol., 1995, vol. 33, no. 2, pp. 497–500.PubMedPubMedCentralGoogle Scholar
  18. 18.
    Held, J., Schmidt, T., Thornton, C.R., Kotter, E., and Bertz, H., Infection, 2013, vol. 41, no. 6, pp. 1163–1169.CrossRefPubMedGoogle Scholar
  19. 19.
    Gustafsdottir, S.M., Schallmeiner, E., Fredriksson, S., Gullberg, M., Soderberg, O., Jarvius, M., Howell, M., and Landegren, U., Anal. Biochem., 2005, vol. 345, no. 1, pp. 2–9.CrossRefPubMedGoogle Scholar
  20. 20.
    White, P.L., Parr, C., Thornton, C., and Barnes, R.A., J. Clin. Microbiol., 2013, vol. 51, no. 5, pp. 1510–1516.CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Karelin, A.A., Tsvetkov, Yu.E., and Nifant’ev, N.E., Usp. Khim., 2017, vol. 86, no. 11.Google Scholar
  22. 22.
    Krylov, V.B., Petruk, M.I., Grigor’ev, I.V., Lebedin, Yu.S., Glushko, N.I., Khaldeeva, E.V., Argunov, D.A., Khatuntseva, E.A., Toplishek, M.V., Komarova, B.S., Karelin, A.A., Yudina, O.N., Men’shov, V.M., Yashunskii, D.V., Tsvetkov, Yu.E., and Nifant’ev, N.E., Russ. J. Bioorg. Chem., 2018, vol. 44, no. 1, pp. 80–89.CrossRefGoogle Scholar
  23. 23.
    Matveev, A.L., Krylov, V.B., Emelyanova, L.A., Solovev, A.S., Khlusevich, Y.A., Baykov, I.K., Fontaine, T., Latge, J.-P., Tikunova, N.V., and Nifantiev, N.E., PLoS One, 2018, vol. 13, e0193938. doi 10.1371/journal.pone.0193938CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Galanina, O.E., Mecklenburg, M., Nifantiev, N.E., Pazynina, G.V., and Bovin, N.V., Lab. Chip, 2003, vol. 3, no. 4, pp. 260–265.CrossRefPubMedGoogle Scholar
  25. 25.
    Tsvetkov, Y.E., Burg-Roderfeld, M., Loers, G., Arda, A., Sukhova, E.V., Khatuntseva, E.A., Grachev, A.A., Chizhov, A.O., Siebert, H.-C., Schachner, M., Jimenez-Barbero, J., and Nifantiev, N.E., J. Am. Chem. Soc., 2012, vol. 134, no. 1, pp. 426–435.CrossRefPubMedGoogle Scholar
  26. 26.
    Argunov, D.A., Krylov, V.B., and Nifantiev, N.E., Org. Biomol. Chem., 2015, vol. 13, no. 11, pp. 3255–3267.CrossRefPubMedGoogle Scholar
  27. 27.
    Argunov, D.A., Krylov, V.B., and Nifantiev, N.E., Org. Lett., 2016, vol. 18, no. 21, pp. 5504–5507.CrossRefPubMedGoogle Scholar
  28. 28.
    Krylov, V.B., Argunov, D.A., Solovev, A.S., Petruk, M.I., Gerbst, A.G., Dmitrenok, A.S., Shashkov, A.S., Latgé, J.-P., and Nifantiev, N.E., Org. Biomol. Chem., 2018, vol. 16, no. 7, pp. 1188–1199.CrossRefPubMedGoogle Scholar
  29. 29.
    Krylov, V.B., Argunov, D.A., Vinnitskiy, D.Z., Verkhnyatskaya, S.A., Gerbst, A.G., Ustyuzhanina, N.E., Dmitrenok, A.S., Huebner, J., Holst, O., Siebert, H.-C., and Nifantiev, N.E., Chem.-Eur. J., 2014, vol. 20, no. 50, pp. 16516–16522.CrossRefPubMedGoogle Scholar
  30. 30.
    Krylov, V.B., Kaskova, Z.M., Vinnitskiy, D.Z., Ustyuzhanina, N.E., Grachev, A.A., Chizhov, A.O., and Nifantiev, N.E., Carbohydr. Res., 2011, vol. 346, no. 5, pp. 540–550.CrossRefPubMedGoogle Scholar
  31. 31.
    Krylov, V.B., Argunov, D.A., Vinnitskiy, D.Z., Gerbst, A.G., Ustyuzhanina, N.E., Dmitrenok, A.S., and Nifantiev, N.E., Synlett., 2016, vol. 27, no. 11, pp. 1659–1664.CrossRefGoogle Scholar
  32. 32.
    Komarova, B.S., Orekhova, M.V., Tsvetkov, Y.E., Beau, R., Aimanianda, V., Latgé, J.P., and Nifantiev, N.E., Chem.-Eur. J., 2015, vol. 21, no. 3, pp. 1029–1035.CrossRefPubMedGoogle Scholar
  33. 33.
    Komarova, B.S., Orekhova, M.V., Tsvetkov, Y.E., and Nifantiev, N.E., Carbohydr. Res., 2014, vol. 384, pp. 70–86.CrossRefPubMedGoogle Scholar
  34. 34.
    Yashunsky, D.V., Tsvetkov, Y.E., Grachev, A.A., Chizhov, A.O., and Nifantiev, N.E., Carbohydr. Res., 2016, vol. 419, pp. 8–17.CrossRefPubMedGoogle Scholar
  35. 35.
    Yashunsky, D.V., Tsvetkov, Y.E., and Nifantiev, N.E., Carbohydr. Res., 2016, vol. 436, pp. 25–30.CrossRefPubMedGoogle Scholar
  36. 36.
    Karelin, A.A., Tsvetkov, Y.E., Paulovicova, E., Paulovicova, L., and Nifantiev, N.E., Eur. J. Org. Chem., 2016, vol. 2016, no. 6, pp. 1173–1181.CrossRefGoogle Scholar
  37. 37.
    Yudina, O.N., Tsvetkov, Yu.E., and Nifant’ev, N.E., Russ. Chem. Bull., 2015, vol. 64, no. 12, pp. 2932–2941.CrossRefGoogle Scholar
  38. 38.
    Yudina, O.N., Tsvetkov, Yu.E., and Nifantiev, N.E., Russ. Chem. Bull., 2016, vol. 65, no. 12, pp. 2937–2942.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • V. B. Krylov
    • 1
  • M. I. Petruk
    • 1
  • N. I. Glushko
    • 2
  • E. V. Khaldeeva
    • 2
  • V. L. Mokeeva
    • 3
  • E. N. Bilanenko
    • 3
  • Y. S. Lebedin
    • 4
  • S. A. Eremin
    • 3
  • N. E. Nifantiev
    • 1
  1. 1.Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussia
  2. 2.Kazan Scientific Research Institute of Epidemiology and MicrobiologyKazanRussia
  3. 3.M.V. Lomonosov State UniversityMoscowRussia
  4. 4.XEMA Company LimitedMoscowRussia

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