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Brainstem structures involved in rapid eye movement sleep behavior disorder

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Abstract

Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by the loss of muscle atonia during paradoxical (REM) sleep (PS). The neuronal dysfunctions responsible for RBD are not known. In the present review, we propose an updated integrated model of the mechanisms responsible for PS and explore different hypotheses explaining RBD. We propose that RBD appears based on a specific degeneration of PS-on glutamatergic neurons localized in the caudal pontine sublaterodorsal tegmental nucleus or the glycinergic/GABAergic premotoneurons localized in the medullary ventral gigantocellular reticular nucleus.

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Authors and Affiliations

  1. INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, Team Physiopathology of the neuronal network of the sleep-waking cycle, France

    Pierre-Hervé Luppi, Olivier ClÉMent & Patrice Fort

  2. University Claude Bernard Lyon 1, France

    Pierre-Hervé Luppi, Olivier ClÉMent & Patrice Fort

  3. University of Lyon, Lyon, France

    Pierre-Hervé Luppi, Olivier ClÉMent & Patrice Fort

  4. UMR5167 CNRS, Faculté de Médecine RTH Laennec, 7, Rue Guillaume Paradin, 69372, Lyon cedex 08, France

    Pierre-Hervé Luppi

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  1. Pierre-Hervé Luppi
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  2. Olivier ClÉMent
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  3. Patrice Fort
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Correspondence to Pierre-Hervé Luppi.

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Luppi, PH., ClÉMent, O. & Fort, P. Brainstem structures involved in rapid eye movement sleep behavior disorder. Sleep Biol. Rhythms 11 (Suppl 1), 9–14 (2013). https://doi.org/10.1111/j.1479-8425.2012.00544.x

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