Skip to main content

Advertisement

Log in

Email-based epidemiological surveys on restless legs syndrome in Japan

  • Original Article
  • Published:
Sleep and Biological Rhythms Aims and scope Submit manuscript

Abstract

The prevalence, clinical significance and awareness of restless legs syndrome (RLS) have not been well identified in Japan. We conducted an Internet-based survey on the general Japanese population. Using an Internet-linked questionnaire, we evaluated 8126 respondents, consisting of a cross-section of Japanese adults aged 20 to 59 years. The questionnaire items consisted of demographic variables, the National Institute of Health/International RLS Study Group (IRLSSG) consensus questionnaire, the IRLSSG rating scale (IRLS), the Pittsburgh sleep quality index (PSQI), and questions regarding diagnosis and treatment. Probable RLS was found in 326 participants (4.01%). The prevalence was significantly higher in women (4.9%) than in men (3.0%), but did not differ by age. Most of the probable participants had mild to moderate IRLS severity and their average PSQI score was significantly higher than in unaffected participants. No probable RLS participants had been diagnosed with RLS, and only 7.7% had sought medical assistance. The prevalence of probable RLS in Japan is higher than in previous reports in Asia and, despite its low severity, the disorder is also thought to contribute to sleep disturbances in affected individuals. RLS is not well recognized in Japan and so promoting RLS awareness is necessary.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Ekbom KA. Restless legs syndrome. Neurology 1960; 10: 863–73.

    Article  Google Scholar 

  2. Allen RP, Picchietti D, Hening WA et al. Restless Legs Syndrome Diagnosis and Epidemiology Workshop at the National Institutes of Health; International Restless Legs Syndrome Study Group. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003; 4: 101–19.

    Article  PubMed  Google Scholar 

  3. Rothdach AJ, Trenkwalder C, Haberstock J, Keil U, Berger K. Prevalence and risk factors of RLS in an elderly population: the MEMO Study. Memory and Morbidity in Augsburg Elderly. Neurology 2000; 54: 1064–8.

    Article  CAS  PubMed  Google Scholar 

  4. Lavigne GJ, Montplaisir JY. Restless legs syndrome and sleep bruxism: prevalence and association among Canadians. Sleep 1994; 17: 739–43.

    CAS  PubMed  Google Scholar 

  5. Chokroverty S, Jankovic J. Restless legs syndrome: a disease in search of identity. Neurology 1999; 52: 907–10.

    Article  CAS  PubMed  Google Scholar 

  6. Tan EK, Seah A, See SJ et al. Restless legs syndrome in an Asian population: a study in Singapore. Mov. Disord. 2001; 16: 577–9.

    Article  CAS  PubMed  Google Scholar 

  7. Mizuno S, Miyaoka T, Inagaki T, Horguchi J. Prevalence of restless legs syndrome in non-institutionalized Japanese elderly. Psychiatry Clin. Neurosci. 2005; 59: 461–5.

    Article  PubMed  Google Scholar 

  8. Littner MR, Kushida C, Anderson WM et al. Treatment resistant group. Practice parameters for the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder. Sleep 2004; 27: 557–9.

    PubMed  Google Scholar 

  9. Hening W, Walters AS, Allen RP et al. Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study. Sleep Med. 2004; 5: 237–46.

    Article  PubMed  Google Scholar 

  10. Allen RP, Walters AS, Montplaisir J et al. Restless legs syndrome prevalence and impact: REST general population study. Arch. Intern. Med. 2005; 165: 1286–92.

    Article  PubMed  Google Scholar 

  11. Tison F, Crochard A, Leger D et al. Epidemiology of restless legs syndrome in French adults. A nationwide survey: The INSTANT Study. Neurology 2005; 65: 239–46.

    Article  CAS  PubMed  Google Scholar 

  12. Rijsman R, Neven AK, Graffelman W et al. Epidemiology of restless legs in The Netherlands. Eur. J. Neurol. 2004; 11: 607–11.

    Article  PubMed  Google Scholar 

  13. Allen RP, Kushida CA, Atkinson MJ, RLS QoL Consortium. Factor analysis of the International Restless Legs Syndrome Study Group’s scale for restless legs severity. Sleep Med. 2003; 4: 133–5.

    Article  PubMed  Google Scholar 

  14. Angelico F, Del Ben M, Francioso S et al. Attitudes and approach to cardiovascular risk factors in Italy: results of an electronic questionnaire survey. Public Health 2003; 117: 242–9.

    Article  PubMed  Google Scholar 

  15. Doi Y, Minowa M, Uchiyama M et al. Psychometric assessment of subjective sleep quality using the Japanese version of the Pittsburgh sleep quality index (PSQI) in psychiatric disordered and control subjects. Psychiatry Res. 2000; 97: 165–72.

    Article  CAS  PubMed  Google Scholar 

  16. The International Restless Legs Syndrome Study Group. Validation of the International Restless Legs Syndrome Study Group rating scale for restless leg syndrome. Sleep Med. 2003; 4: 121–32.

    Article  Google Scholar 

  17. Im EO, Chee W. Recruitment of research participants through the Internet. Comput. Inform. Nurs. 2004; 22: 289–97.

    Article  PubMed  Google Scholar 

  18. Sevim S, Dogu O, Camdeviren H et al. Unexpectedly low prevalence and unusual characteristics of RLS in Mersin, Turkey. Neurology 2003; 61: 1562–9.

    Article  CAS  PubMed  Google Scholar 

  19. Hogl B, Kiechl S, Willeit J et al. Restless legs syndrome: a community-based study of prevalence, severity, and risk factors. Neurology 2005; 64: 1920–4.

    Article  CAS  PubMed  Google Scholar 

  20. Bjorvatn B, Leissner L, Ulfberg J et al. Prevalence, severity and risk factors of restless legs syndrome in the general adult population in two Scandinavian countries. Sleep Med. 2005; 6: 307–12.

    Article  PubMed  Google Scholar 

  21. Berger K, Luedemann J, Trenkwalder C et al. Sex and the risk of restless legs syndrome in the general population. Arch. Intern. Med. 2004; 164: 196–202.

    Article  PubMed  Google Scholar 

  22. Kageyama T, Kabuto M, Nitta H et al. Prevalences of periodic limb movement-like and restless legs-like symptoms among Japanese adults. Psychiatry Clin. Neurosci. 2000; 54: 296–8.

    Article  CAS  PubMed  Google Scholar 

  23. Kim J, Choi C, Shin K et al. Prevalence of restless legs syndrome and associated factors in the Korean adult population: the Korean Health and Genome Study. Psychiatry Clin. Neurosci. 2005; 59: 350–3.

    Article  PubMed  Google Scholar 

  24. Enomoto M, Li L, Aritake S et al. Restless legs syndrome and its correlation with other sleep problems in the general adult population. Sleep Biol. Rhythms 2006; 4: 153–9.

    Article  Google Scholar 

  25. Nichols DA, Kushida C, Allen R et al. Validation of RLS diagnostic questions in a primary care practice [Abstract]. Sleep 2003; 26: A346.

    Google Scholar 

  26. Nomura T, Inoue Y, Miyake M et al. Prevalence and clinical characteristics of restless legs syndrome in Japanese patients with Parkinson’s disease. Mov. Disord. 2006; 21: 380–4.

    Article  PubMed  Google Scholar 

  27. Kawauchi A, Inoue Y, Hachimoto T et al. Restless legs syndrome in hemodialysis patients: health-related quality of life and laboratory data analysis. Clin. Nephrol. 2006; 66: 440–6.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Takashi Nomura.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nomura, T., Inoue, Y., Kusumi, M. et al. Email-based epidemiological surveys on restless legs syndrome in Japan. Sleep Biol. Rhythms 6, 139–145 (2008). https://doi.org/10.1111/j.1479-8425.2008.00349.x

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1111/j.1479-8425.2008.00349.x

Key words

Navigation