Revisit Kaplan-Meier Estimator in Estimating QAL Survival Distributions
Quality-adjusted lifetime (QAL) is an important component in evaluation of clinical trials. In a seminal paper, Gelber et al. (1989) claimed that the Kaplan-Meier estimator is inconsistent in estimating the distribution of QAL under the presence of censoring. However, in this article, we show that, with appropriate censoring indexing, the Kaplan-Meier estimator actually is consistent in some practically important QAL data settings.
KeywordsKaplan-Meier estimator Quality-adjusted lifetime Survival analysis Zhao-Tsiatis estimator
MSCPrimary 62N02 Secondary 62G05
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