Neurological entanglements: The case of paediatric depressions, SSRIs and suicidal ideation
- 153 Downloads
This article explores the neurological entanglements that are the stuff of depressive states in treatment. My particular concern is the use of selective serotonin reuptake inhibitors in depressed paediatric populations. The use of antidepressants to treat childhood and adolescent depressions has become more frequent in recent years, and more controversial. My ambition is not to intervene into these debates directly, but to push some of our thinking about the substrata of depression in new directions. I am interested in what philosophies of the body and what theories of mind the psychological literatures about paediatric depression lean on, and silently promote. Drawing on neurological and clinical trial data, the article argues that depressive states are neither caused nor cured by singular events (a gene; a pharmaceutical); rather they are complex, non-deterministic sedimentations of pharmaco-affective, ideo-chemical and neuro-social affiliations.
Keywordsneuroscience depression SSRI childhood intra-action
- American Psychiatric Association. (2000) Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR). Arlington, TX: American Psychiatric Association.Google Scholar
- Birmes, P., Coppin, D., Schmitt, L. and Lauque, D. (2003) Serotonin syndrome: A brief review. Canadian Medical Association Journal 168 (11): 1439–1442.Google Scholar
- Committee for Safety of Medicines. (2004) Report of the CSM Expert Working Group on the Safety of Selective Serotonin Reuptake Inhibitor Antidepressants, http://www.mhra.gov.uk/Safetyinformation/Safetywarningsalertsandrecalls/Safetywarningsandmessagesformedicines/CON1004259.
- European Medicines Agency. (2005) European Medicines Agency finalises review of antidepressants in children/adolescents, http://www.ahrp.org/infomail/05/04/26.php, accessed 25 May 2011.
- Fleischer, R. (dir.) (1966) Fantastic Voyage, Twentieth Century Fox Film Corporation.Google Scholar
- Freud, S. (1909/1955) Notes upon a case of obsessional neurosis. In: J. Strachey (ed.) The Standard Edition of the Complete Psychological Works of Sigmund Freud, Vol. 10. London: Hogarth Press, pp. 155–249.Google Scholar
- Garland, E.J., Kutcher, S. and Virani, A. (2009) 2008 position paper on using SSRIs in children and adolescents. Journal of Canadian Academy of Child and Adolescent Psychiatry 18 (2): 160–165.Google Scholar
- Goffman, E. (1961) Asylums: Essays on the Social Situation of Mental Patients and Other Inmates. New York: Anchor Books.Google Scholar
- Healy, D. (1999) The Antidepressant Era. Cambridge, MA: Harvard University Press.Google Scholar
- Healy, D. (2004) Let Them Eat Prozac. The Unhealthy Relationship between the Pharmaceutical Industry and Depression. New York: New York University Press.Google Scholar
- Laing, R.D. and Esterson, A. (1964) Sanity, Madness and the Family. Harmondsworth, UK: Penguin.Google Scholar
- National Institute for Health and Clinical Excellence [NICE]. (2005) Depression in Children and Young People (Quick Reference Guide), Clinical Guideline 28: September. London: National Institute for Health and Clinical Excellence.Google Scholar
- Rose, N. (1990) Governing the Soul: The Shaping of the Private Self. London: Routledge.Google Scholar
- Timimi, S. (2002) Pathological Child Psychiatry and the Medicalization of Childhood. New York: Brunner-Routledge.Google Scholar
- Tomkins, S. (1963) Affect, Imagery, Consciousness. Volume II. The Negative Affects. New York: Springer.Google Scholar
- US Food and Drug Administration. (2007) Revisions to product labeling, http://www.fda.gov/downloads/Drugs/DrugSafety/InformationbyDrugClass/UCM173233.pdf, accessed 25 May 2011.
- Wheeler, B., Gunnell, D., Metcalfe, C., Stephens, P. and Martin, R. (2008) The population impact on incidence of suicide and non-fatal self harm of regulatory action against the use of selective serotonin reuptake inhibitors in under 18s in the United Kingdom: Ecological study. British Medical Journal 336: 542–545.CrossRefGoogle Scholar
- Wilson, E.A. (1998) Neural Geographies: Feminism and the Microstructure of Cognition. New York: Routledge.Google Scholar