Advertisement

Journal of Assisted Reproduction and Genetics

, Volume 21, Issue 1, pp 15–17 | Cite as

Preimplantation Diagnosis (PGD)—A European Clinician's Point of View

  • Wilfried Feichtinger
Article

Abstract

This paper describes the current status of preimplantation diagnosis from the viewpoint of an experienced clinician specialized in reproductive medicine. Current progress and international experiences with different applications and techniques are being reviewed on the basis of the literature. Particular interest is focused on possible advantages of routinely diagnosing major chromosome aneuploidies in preimplantation-embryos of patients undergoing in vitro fertilization and embryo transfer. Last but not least, a short survey of the international guidelines and legislation is compared to the situation in the author's country, Austria, where it is currently unclear whether preimplantation diagnosis is allowed or not.

Preimplantation diagnosis in vitro fertilization assisted reproductive technology infertility polar body aneuploidy genetic and chromosomal disorders 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

REFERENCES

  1. 1.
    Verlinsky Y, Kuliev A: Preimplantation genetics. J Assist Reprod Genet 1998;5:215-218.Google Scholar
  2. 2.
    Handyside AH, Kontogianni EH, Hardy K, Winston RML: Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification. Nature 1990;244:768-770.Google Scholar
  3. 3.
    Verlinsky Y: Current progress in preimplantation genetic diagnosis. J Assist Reprod Genet 1993;10:353-360.Google Scholar
  4. 4.
    Kuliev A, Rechitsky S, Verlinsky O, Ivakhnenko V, Evsikov S, Wolf G, Angastinlotis M, Geoghiou D, Kukharenko V, Strom C, Verlinsky Y: Preimplantation diagnosis of thalassemia. J Assist Reprod Genet 1998;15:219-225.Google Scholar
  5. 5.
    Pickering S, Polidoropoulos N, Caller J, Scriven P, Ogilvie CM, Braude P: Strategies and outcomes of the first 100 cycles of preimplantation genetic diagnosis at the Guy's and St. Thomas Center Fertil Steril 2003;79:81-90.Google Scholar
  6. 6.
    Verlinsky Y, Ginsberg N, Lifchez A, Valie J, Moise J, Strom CM: Analysis of the first polar body: Preconception genetic diagnosis. Hum Reprod 1990;5:826-829.Google Scholar
  7. 7.
    Verlinsky Y, Cieslak J, Ivakhnenko V, Evsikov S, Wolf G, White M, Lifchez A, Kaplan B, Moise, Valle J, Ginsberg N, Strom C, Kuliev A. Preimplantation diagnosis of common aneuploides by the first and second polar body FISH analysis. J Assist Reprod Genet 1998;15:285-289.Google Scholar
  8. 8.
    Munné S, Lee A, Rosenwaks Z, Grifo, Cohen J. Diagnosis of major chromosome aneuploidies in human preimplantation embryos. Hum Reprod 1993;8:2185-2191.Google Scholar
  9. 9.
    Magli MC, Gianaroli L, Munné S, Ferraretti AP: Incidence of chromosonial abnormalities from a morphologically normal cohort of embryos in poor-prognosis patients. J Assist Reprod Genet 1998;15:297-301.Google Scholar
  10. 10.
    Montag M, van der Veen K, van der Veen H: Erste klinische Erfahrungen mit der Polkörperdiagnostik in Deutschland. J Fertil Reprod 2002;4:7-9.Google Scholar
  11. 11.
    van der Veen H, Montag M, van der Veen K: Schwangerschaft nach Polkörperbiopsie und Fluoreszenz-in situ-Hybridisierung (FISH) der Chromosomen 13, 16, 18, 21 und 22. Geb Frau 2002;62:585-588.Google Scholar
  12. 12.
    Munné S, Cohen J, Sable D: Preimplantation genetic diagnosis for advanced maternal age and other indications. Fertil Steril 2002;78:234-236.Google Scholar
  13. 13.
    Hassold T, Chiu D. Maternal age specific rates of numerical chromosome abnormalities with special reference to trisomy. Hum Genet 1985;70:11-17.Google Scholar
  14. 14.
    Vidal F, Gimenez C, Rubio C, Simon C, Pellicer A, Santalo J, Egozcue J: FISH preimplantation diagnosis of chromosome aneuploidy in recurrent pregnancy wastage. J Assist Reprod Genet 1998;15:310-313.Google Scholar
  15. 15.
    Munné S, Alikani M, Tomkin G, Grifo J, Cohen J: Embryo morphology, developmental rates and maternal age are correlated with chromosome abnormalities. Fertil Steril 1995;64:382-391.Google Scholar
  16. 16.
    Werlin LB, Escudero T, Marello EC, Velilla E, Sandalinas M, Nass TE, Munné S: Preimplantation genetic diagnosis (PGD) as both a diagnostic and therapeutic tool in women with advanced maternal age (AMA) undergoing IVF. Fertil Steril 2002;77(Suppl. 3):13-14.Google Scholar
  17. 17.
    Fortpflanzungsmedizingesetz--FMedG. Bundesgesetzblatt für die Republik österreich 1992;275:1299-1303.Google Scholar
  18. 18.
    Bernat E: Der menschliche Keim als Objekt des Forschers. Rechtsethische und rechtsvergleichende überlegungen. In Eingriffe in die menschliche Keimbahn, W Bender, GH Gassen, K Platzer, B Seehaus (Hrsg.) Agenda Verlag Münster, Germany, 2000, pp 57-82.Google Scholar

Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • Wilfried Feichtinger
    • 1
  1. 1.WunschbabyzentrumViennaAustria

Personalised recommendations