Abstract
Purpose : To investigate whether the consecutive embryo transfer of day 3 embryos and of blastocyst protects against failure to reach embryo transfer and provides additional pregnancies.
Methods : An embryo transfer was performed on day 3 following which all remaining embryos were cultured to the blastocyst stage for a possible second transfer.
Results : One hundred and forty-two patients were selected for extended culture. Thirty-two of these patients did not develop blastocysts in culture, however, there were 12 pregnancies achieved in this group.
Conclusions : The consecutive transfer of day 3 embryos and blastocysts can prevent the total loss of a cycle when embryos fail to develop to the blastocyst stage in culture and thereby provide additional pregnancies.
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REFERENCES
Gardner DK, Vella P, Lane M, Wagley L, Schlenker T, Schoolcraft WB: Culture and transfer of human blastocysts increases implantation rates and reduces the need for multiple embryo transfers. Fertil Steril 1998;69:84–88
Alper MM, Brinsden P, Fischer R, Wikland M: To blastocyst or not to blastocyst? That is the question. Hum Reprod 2001;16(4):617–619
Scholtes MCW, Zeilmaker GH: Blastocyst transfer in day-5 embryo transfer depends primarily on the number of oocytes retrieved and not on age. Fertil Steril 1998;69:78–83
Huisman GJ, Fauser BC, Eijkemans MJ, Pieters MH: Implantation rates after in vitro fertilization and transfer of a maximum of two embryos that have undergone three to five days of culture. Fertil Steril 2000;73(1):117–122
Ashkenazi J, Yoeli R, Orvieto R, Shalev J, Ben-Rafael Z, Bar-Hava I: Double (consecutive) transfer of early embryos and blastocysts: Aims and results. Fertil Steril 2000;74(5): 936–940
Dean NL, Phillips SJ, Buckett WM, Biljan MM, Tan SL: Impact of reducing the number of embryos transferred from three to two in women under the age of 35 who produced three or more high quality embryos. Fertil Steril 2000;74:820–823
Biljan MM, Dean N, Hemmings R, Bissonnette F, Tan SL: Prospective randomized study of the effect of two flushing media on oocyte collection and fertilization rates after in vitro fertilization. Fertil Steril 1997;68(6):1132–1134
Coskun S, Hollanders J, Al-Hassan S, Al-Sufyan H, Al-Mayman H, Jaroudi K: Day 5 versus day 3 embryo transfer: A controlled randomized trial. Hum Reprod 2000;15(9):1947–1952
Scott L, Alvero R, Leondires M, Miller B: The morphology of human pronuclear embryos is positively related to blastocyst development and implantation. Hum Reprod 2000;15(11):2394–2403
Gardner DK, Lane M, Stevens J, Schoolcraft WB: Noninvasive assessment of human embryo nutrient consumption as a measure of developmental potential. Fertil Steril 2001;76(6):1175–1180
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Phillips, S.J., Dean, N.L., Buckett, W.M. et al. Consecutive Transfer of Day 3 Embryos and of Day 5–6 Blastocysts Increases Overall Pregnancy Rates Associated with Blastocyst Culture. J Assist Reprod Genet 20, 461–464 (2003). https://doi.org/10.1023/B:JARG.0000006708.26464.23
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DOI: https://doi.org/10.1023/B:JARG.0000006708.26464.23