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4-Oxo-3,4-dihydroquinazolinyl- and Benzimidazolylacetonitriles in Annelation Reactions of a Haloquinoline Ring

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The interaction of 4-oxo-3,4-dihydroquinazolinyl- and benzimidazolylacetonitriles with 2,6-dihalobenzaldehydes leads to 3-(2,6-dihalophenyl)-2-(4-oxo-3,4-dihydro-2-quinazolinyl)acrylonitriles and 2-(1H-benzo[d]imidazol-2-yl)-3-(2,6-dihalophenyl)acrylonitriles respectively. As a result of intramolecular cyclization of these nitriles 4-halo-12-oxo-12H-quino[2,1-b]quinazoline-6-carbonitriles and 4-halobenzo[4,5]imidazo[1,2-a]quinoline-6-carbonitriles respectively are formed.

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Authors and Affiliations

  1. Kiev Taras Shevchenko National University, Kiev, 01033, Ukraine

    O. V. Khilya, T. A. Volovnenko, A. V. Turov & Yu. M. Volovenko

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  1. O. V. Khilya
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  2. T. A. Volovnenko
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  3. A. V. Turov
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  4. Yu. M. Volovenko
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Khilya, O.V., Volovnenko, T.A., Turov, A.V. et al. 4-Oxo-3,4-dihydroquinazolinyl- and Benzimidazolylacetonitriles in Annelation Reactions of a Haloquinoline Ring. Chemistry of Heterocyclic Compounds 40, 1063–1069 (2004). https://doi.org/10.1023/B:COHC.0000046698.75658.49

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  • DOI: https://doi.org/10.1023/B:COHC.0000046698.75658.49

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