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Regioselective Synthesis and Properties of 6-Amino-3-carbamoyl-5-cyano-3,4-dihydrospirocyclohexane-4-pyridine-2-thiol and 5-Cyano-3-thiocarbamoyl-4-spirocyclohexanepiperidine-2,6-dione

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Abstract

Treatment of monothiomalonodiamide with cyclohexylidenemalononitrile or cyclohexylidenecyanoacetic ester in the presence of sodium ethylate gave 6-amino-3-carbamoyl-5-cyano-3,4-dihydrospirocyclohexane-4-pyridine-2-thiol and 5-cyano-3-thiocarbamoyl-4-spirocyclohexanepiperidine-2,6-dione. Their alkylation and hydrolysis have been studied.

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Authors and Affiliations

  1. Taras Shevchenko State Pedagogical University, Lugansk, 91011, Ukraine

    A. D. Dyachenko & V. D. Dyachenko

  2. V. N. Karazin Kharkov National University, Kharkov, 61070, Ukraine

    S. M. Desenko

Authors
  1. A. D. Dyachenko
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  2. S. M. Desenko
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  3. V. D. Dyachenko
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Dyachenko, A.D., Desenko, S.M. & Dyachenko, V.D. Regioselective Synthesis and Properties of 6-Amino-3-carbamoyl-5-cyano-3,4-dihydrospirocyclohexane-4-pyridine-2-thiol and 5-Cyano-3-thiocarbamoyl-4-spirocyclohexanepiperidine-2,6-dione. Chemistry of Heterocyclic Compounds 40, 1017–1023 (2004). https://doi.org/10.1023/B:COHC.0000046691.85029.7a

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  • DOI: https://doi.org/10.1023/B:COHC.0000046691.85029.7a

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