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11-Aryl-3,3-dimethyl-7- and 7,8-Substituted 1,2,3,4,10,11-Hexahydro-5H-dibenzo[b,e]-1,4-diazepin-1-ones

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

In reactions of 3-(5- and 5,6-substituted 2-aminophenylamino)-5,5-dimethylcyclohex-2-en-ones with carbaldehydes of pyridine, thiophene, and furan and substituted benzaldehydes, we have obtained 21 novel 7H-7-methoxycarbonyl-, 7-benzoyl-, 7-trifluoromethyl-, 7-nitro- and 7,8-dichloro-11-aryl-3,3-dimethyl-1,2,3,4,10,11-hexahydro-5H-dibenzo[b,e]-1,4-diazepin-1-one.

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REFERENCES

  1. Y. Blache, M. Hichour, G. Di Blasi, J.-M. Chezal, H. Viols, O. Chavingnon, J. C. Taulade, and J. P. Chapat, Heterocycles, 51, 1003 (1999).

    Google Scholar 

  2. T. Watanabe, I. Kinoyama, K. Takizawa, S. Hirano, and T. Shibanuma, Chem. Pharm. Bull., 47, 672 (1999).

    Google Scholar 

  3. T. Watanabe, A. Kakefuda, A. Tanaka, K. Takizawa, S. Hirano, H. Shibata, Y. Yamaguva, and I. Yanagisava, Chem. Pharm. Bull., 46, 53 (1998).

    Google Scholar 

  4. C. L. Cywin, J. M. Klunder, M. A. Hoermann, J. R. Brickwood, E. David, R. Schwartz, D. Pauletti, K. J. Barringer, Ch. L. Sorge, D. A. Erickson, D. P. Joseph, and S. E. Hattox, J. Med. Chem., 41, 2972 (1998).

    Google Scholar 

  5. T. A. Kelly, D. W. McNeil, J. M. Rose, E. David, Cheng-Kon Shin, and P. M. Grob, J. Med. Chem., 40, 2430 (1997).

    Google Scholar 

  6. G. Heinisch and B. Matuszak, J. Heterocycl. Chem., 34, 1421 (1997).

    Google Scholar 

  7. T. Watanabe, A. Kakefuda, I. Kinoyama, K. Takizawa, S. Hirano, H. Shibata, and I. Yanagisava, Chem. Pharm. Bull., 45, 1458 (1997).

    Google Scholar 

  8. T. Watanabe, I. Kinoyama, A. Kakefuda, T. Okazaki, K. Takizawa, S. Hirano, H. Shibata, and I. Yanagisava, Chem. Pharm. Bull., 45, 996 (1997).

    Google Scholar 

  9. J. R. Proudfoot, U. R. Patel, S. R. Kapadia, and K. Hargrave, J. Med. Chem., 38, 1406 (1995).

    Google Scholar 

  10. T. A. Kelly, D. W. McNeil, U. R. Patel, E. David, K. D. Hargrave, P. M. Grob, M. Cardozo, A. Agarwal, and J. Adams, J. Med. Chem., 38, 4839 (1995).

    Google Scholar 

  11. A. Minarini, M. L. Bolognesi, R. Budriesi, M. Canossa, A. Chiarini, S. Spampinato, and C. Melchiorre, J. Med. Chem., 37, 3363 (1994).

    Google Scholar 

  12. N. N. Tonkikh, A. Strakovs, and M. V. Petrova, Khim. Geterotsikl. Soedin., 1095 (2004).

  13. T. Kametani, M. Ihara, and K. Takahashi, Chem. Pharm. Bull., 20, 1588 (1972).

    Google Scholar 

  14. K. Matsuo, M. Ohta, and K. Tanaka, Chem. Pharm. Bull., 33, 4063 (1985).

    Google Scholar 

  15. M. A. Likhate and P. S. Fernandes, J. Indian Chem. Soc., 67, No. 7, 609 (1990).

    Google Scholar 

  16. N. Rashed, M. Sayed, and E. S. H. El Ashry, J. Chin. Chem. Soc., 40, 189 (1993); Chem. Abstr.,119, 139194 (1993).

    Google Scholar 

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Tonkikh, N.N., Strakovs, A., Rizhanova, K.V. et al. 11-Aryl-3,3-dimethyl-7- and 7,8-Substituted 1,2,3,4,10,11-Hexahydro-5H-dibenzo[b,e]-1,4-diazepin-1-ones. Chemistry of Heterocyclic Compounds 40, 949–955 (2004). https://doi.org/10.1023/B:COHC.0000044581.23486.59

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  • DOI: https://doi.org/10.1023/B:COHC.0000044581.23486.59

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