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Chemistry of Heterocyclic Compounds

, Volume 40, Issue 7, pp 944–948 | Cite as

10-Aryl-7,7-dimethyl-5,6,7,8,9,10-hexahydro-11H-pyrido[3,2-b][1,4]benzodiazepin-9-ones

  • N. N. Tonkikh
  • A. Strakovs
  • M. V. Petrova
Article

Abstract

In reactions of 3-(2-amino-3-pyridyl)amino-5,5-dimethylcyclohex-2-en-1-one with aromatic aldehydes (2- and 4-hydroxy-, 2-hydroxy-3-methoxy-, 4-dimethylamino-, 4-methoxy-, 2,4- and 3,4-dimethoxy-, 3,4-methylenedioxy-, 4-bromo-, 4-fluoro-, 4-chloro-, 2-nitro- and 3-nitrobenzaldehydes, furfural, and 2-thiophenecarbaldehyde), we have obtained the corresponding 10-aryl-7,7-dimethyl-5,6,7,8,9,10-hexahydro-11H-pyrido[3,2-b][1,4]benzodiazepin-9-ones.

aromatic aldehydes 2,3-diaminopyridine dimedone pyrido[3,2-b][1,4]benzodiazepine derivatives 

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REFERENCES

  1. 1.
    A. Strakovs, M. V. Petrova, N. N. Tonkikh, E. E. Brooks, S. J. Biehle, and G. P. Kreishman, J. Org. Chem., 64, 1462 (1999).Google Scholar
  2. 2.
    N. N. Tonkikh, A. Strakovs, M. V. Petrova, V. V. Chernyshev, and H. Schenk, Khim. Geterotsikl. Soedin., 822 (2002).Google Scholar
  3. 3.
    R. Martinez, E. Angeles, and F. Martinez, Heterocycl. Commun., 2, 47 (1996).Google Scholar
  4. 4.
    N. Rashed, M. Sayed, and E. S. H. El-Ashry, J. Chin. Chem. Soc., 40, 189 (1993); Chem. Abstr. 119, 139194 (1993).Google Scholar
  5. 5.
    E. J. J. Vanden, A. Mayence, A. Magnestian, and E. Andrs, Bull. Soc. Chim. Belg., 101, 801 (1992).Google Scholar
  6. 6.
    M. A. Lukhate and P. S. Fernandes, J. Indian Chem. Soc., 67, 609 (1990).Google Scholar
  7. 7.
    S. Miyano and N. Abe, Chem. Pharm. Bull., 20, 1588 (1972).Google Scholar
  8. 8.
    Y. Blache, M. Hichour, G. Di Blasi, J.-M. Chezal, H. Viols, O. Chavignon, J.-C. Taulade, and J.-P. Chapat, Heterocycles, 51, 1003 (1999).Google Scholar
  9. 9.
    T. Watanabe, I. Kinoyama, K. Takizawa, S. Hirano, and T. Shibanuma, Chem. Pharm. Bull., 47, 672 (1999).Google Scholar
  10. 10.
    T. Watanabe, I. Kinoyama, A. Kakefuda, T. Okazaki, K. Takizawa, S. Hirano, H. Shibata, and I. Yanagisawa, Chem. Pharm. Bull., 45, 996 (1997).Google Scholar
  11. 11.
    F. X. Woolard, J. Paetsch, and J. A. Ellman, J. Org. Chem., 62, 6102 (1997).Google Scholar

Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • N. N. Tonkikh
  • A. Strakovs
  • M. V. Petrova

There are no affiliations available

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