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Chemistry of Heterocyclic Compounds

, Volume 40, Issue 7, pp 931–937 | Cite as

Candida Rugosa Lipase-catalyzed Kinetic Resolution of 3-(Isobutyryloxy)methyl 4-[2-(Difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate

  • A. Sobolev
  • R. Zhalubovskis
  • M. C. R. Franssen
  • B. Vigante
  • B. Chekavichus
  • G. Duburs
  • Ae. de Groot
Article

Abstract

The lipase-catalyzed kinetic resolution of 3-(isobutyryloxy)methyl 4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate has been performed. The most enantioselective reaction (E = 28) was transesterification with n-butanol in water-saturated toluene at 45°C.

enantiopure 1,4-dihydropyridines enzyme-catalyzed reaction kinetic resolution transesterification 

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Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • A. Sobolev
  • R. Zhalubovskis
  • M. C. R. Franssen
  • B. Vigante
  • B. Chekavichus
  • G. Duburs
  • Ae. de Groot

There are no affiliations available

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