Abstract
The direction of the cyclocondensation of 2-fluoro-5-nitrobenzaldehyde with five amidines having α-hydrogen atoms has been studied. It was established that depending on the structure of the amidine the main products of the reaction may be not only quinazolines but also 3-aminoisoquinolines. A new convenient route has been found for the synthesis of 3-aminoisoquinolines consisting of the cyclocondensation of α-acylacetamidines with 2-fluoro-5-nitrobenzaldehyde.
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Dar'in, D.V., Selivanov, S.I., Lobanov, P.S. et al. Cyclocondensation of 2-Fluoro-5-nitrobenzaldehyde with Amidines. New Synthesis of Isoquinolines. Chemistry of Heterocyclic Compounds 40, 888–894 (2004). https://doi.org/10.1023/B:COHC.0000044571.89322.4e
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DOI: https://doi.org/10.1023/B:COHC.0000044571.89322.4e