Abstract
It has been established that diphenylphosphine oxide reacts smoothly with β-aroylacrylic acids with the formation of β-aroyl-α-diphenylphosphorylpropionic acids, which were cyclized under the action of hydroxylamine, hydrazine hydrate, and phenylhydrazine hydrochloride into phospho derivatives of dihydrooxazinone and tetrahydropyridazinone respectively. It was shown that imidazole may serve as nucleophilic protection for the synthesis of dihydropyridazinone derivatives from β-aroylacrylic acids.
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Khachatryan, R.A., Khachikyan, R.J., Karamyan, N.V. et al. Synthesis and Heterocyclization of β-Aroyl-α-diphenylphosphorylpropionic Acids. Chemistry of Heterocyclic Compounds 40, 446–451 (2004). https://doi.org/10.1023/B:COHC.0000033535.93962.f5
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DOI: https://doi.org/10.1023/B:COHC.0000033535.93962.f5