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Chemistry of Heterocyclic Compounds

, Volume 40, Issue 2, pp 194–202 | Cite as

Two Directions of the Reaction of 4-Bromobenzaldehyde with Substituted Acetophenones and Urea. Synthesis of Aryl-substituted Pyrimidin-2-one and Hexahydropyrimido[4,5-d]pyrimidin-2,7-dione

  • V. F. Sedova
  • O. P. Shkurko
Article

Abstract

Condensation of 4-bromobenzaldehyde, urea, and 4-alkyl-substituted acetophenones gave substituted hexahydro-1H,8H-pyrimido[4,5-d]pyrimidin-2,7-diones or 1H-pyrimidin-2-ones, depending on the substituent on the acetophenone ring and the nature of the solvent (i-PrOH, BuOH, AcOH). The corresponding 5-bromopyrimidin-2-ones were formed on bromination of these compounds. The structures of these compounds were confirmed by IR, UV, and 1H NMR spectroscopy.

4-alkylacetophenones aminopyrimidines 4-bromoacetaldehyde 5-bromo-1H-pyrimidin-2-ones hexahydro-1H,8H-pyrimido[4,5-d]pyrimidin-2,7-diones 4,6-diaryl-1H-pyrimidin-2-ones chloropyrimidines bromination condensation 

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Copyright information

© Plenum Publishing Corporation 2004

Authors and Affiliations

  • V. F. Sedova
    • 1
  • O. P. Shkurko
    • 1
  1. 1.N. N. Vorozhstsov Novosibirsk Institute of Organic ChemistrySiberian Branch of the Russian Academy of SciencesNovosibirsk

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