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Trifluoromethyl-substituted Di- and Tetrahydroazolopyrimidines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The condensation of 4,4,4-trifluoro-1-phenylbut-1-en-3-one with 2-aminobenzimidazole, 3-amino-1,2,4-triazole, and 5-aminotetrazole gives hydroxy-substituted tetrahydro derivatives of pyrimido[1,2-a]benzimidazole, and of 1,2,4-triazolo-, and tetrazolo[1,5-a]pyrimidine. Dehydration of them to the corresponding dihydroazolopyrimidines has been carried out. An X-ray structural investigation was carried out and the molecular structure of 5-hydroxy-7-phenyl-5-trifluoromethyl-4,5,5,7-tetrahydrotetrazolo[1,5-a]pyrimidine is discussed.

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REFERENCES

  1. V. G. Nenaidenko, A. V. Sanin, and E. S. Balenkova, Usp. Khim., 68, 483 (1999).

    Google Scholar 

  2. S. M. Desenko, Khim. Geterotsikl. Soedin., 147 (1995).

  3. G. Hajos, A. Messmer, A. Neszmelyi, and L. Parkanyi, J. Org. Chem., 49, 3199 (1984).

    Google Scholar 

  4. M. M. Goodman, J. L. Atwood, R. Carlin, W. Hunter, and W. W. Paudler, J. Org. Chem., 41, 2860 (1976).

    Google Scholar 

  5. J. Zabrocki, G. D. Smith, J. B. Dunbar Jr., H. Lijima, and G. R. Marshall, J. Am. Chem. Soc., 110, 5875 (1988).

    Google Scholar 

  6. H. B. Burgi and J. D. Dunitz, Structure Correlation, Vol. 2, VCH, Weinheim (1994), p. 741.

    Google Scholar 

  7. N. S. Zefirov and P. M. Zorkii, Usp. Khim., 58, 713 (1989).

    Google Scholar 

  8. G. M. Sheldrick, SHELX97. PC Version. A System of Computer Programs for Crystal Structure Solution and Refinement. Rev. 2 (1998).

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Desenko, S.M., Gladkov, E.S., Nenaidenko, V.G. et al. Trifluoromethyl-substituted Di- and Tetrahydroazolopyrimidines. Chemistry of Heterocyclic Compounds 40, 65–69 (2004). https://doi.org/10.1023/B:COHC.0000023769.66759.7d

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  • DOI: https://doi.org/10.1023/B:COHC.0000023769.66759.7d

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