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Synthesis of 4,5-Dihydro-1,3,4-thiadiazole-2-carboxamide and 2-Carbamoyl-4,5-dihydro-1,3,4-thiadiazole 1-Oxide Derivatives Based on Hydrazones of Oxamic Acid Thiohydrazides

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

We have developed a method for obtaining derivatives of 4,5-dihydro-1,3,4-thiadiazole-2-carboxamide by acylation of hydrazones of oxamic acid thiohydrazides. Oxidation of the dihydrothiadiazole ring of the indicated products by hydrogen peroxide leads to formation of 2-carbamoyl-4,5-dihydro-1,3,4-thiadiazole 1-oxides.

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Authors and Affiliations

  1. Russian Academy of Sciences, N. D. Zelinsky Institute of Organic Chemistry, Moscow, 119991

    V. N. Yarovenko, A. V. Shirokov, I. V. Zavarzin, O. N. Krupinova, A. V. Ignatenko & M. M. Krayushkin

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  1. V. N. Yarovenko
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  2. A. V. Shirokov
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  3. I. V. Zavarzin
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  4. O. N. Krupinova
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  5. A. V. Ignatenko
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  6. M. M. Krayushkin
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Yarovenko, V.N., Shirokov, A.V., Zavarzin, I.V. et al. Synthesis of 4,5-Dihydro-1,3,4-thiadiazole-2-carboxamide and 2-Carbamoyl-4,5-dihydro-1,3,4-thiadiazole 1-Oxide Derivatives Based on Hydrazones of Oxamic Acid Thiohydrazides. Chemistry of Heterocyclic Compounds 39, 1633–1639 (2003). https://doi.org/10.1023/B:COHC.0000018342.57499.16

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  • DOI: https://doi.org/10.1023/B:COHC.0000018342.57499.16

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