Abstract
4,4-Dialkyl-substituted N-methylmorpholinium 3,5-dicyano-6-oxo-1,4,5,6-tetrahydropyridine-2-thiolates were synthesized by the condensation of 2-alkyl-2-cyanoethyl crotonates with cyanothioacetamide and N-methylmorpholine. They were used for the production of substituted 2-alkylthio-1,4,5,6-tetrahydropyridines, 2-acetylthio-1,4,5,6,-tetrahydropyridine, 6-hydrazino-1,4,5,6-tetrahydropyridine, and 2,3,4,5,6,7-hexahydrothiazolo[3,2-a]pyridine. The structure of 6-bromo-3-bromomethyl-6,8-dicyano-7,7-dimethyl-2,3,4,5,6,7-hexahydrothiazolo[3,2-a]pyridine was proved by X-ray crystallographic analysis.
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Dyachenko, V.D., Nikishin, A.A. & Chernega, A.N. 4,4-Dialkyl-substituted N-Methylmorpholinium 3,5-Dicyano-6-oxo-1,4,5,6-tetrahydropyridine-2-thiolates and Some of Their Properties. Chemistry of Heterocyclic Compounds 39, 1153–1160 (2003). https://doi.org/10.1023/B:COHC.0000008259.47550.0b
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DOI: https://doi.org/10.1023/B:COHC.0000008259.47550.0b