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Clinicopathological Significance of GADD45 Gene Alterations in Human Familial Breast Carcinoma

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Abstract

GADD45 is a DNA damage responsive gene, induced following BRCA1 expression. Mutations at GADD45 might substitute for p53 alterations in hereditary breast tumours characterized by wild-type p53. We analyzed GADD45 alterations in 59 (15 BRCA-associated) familial breast carcinomas. No mutations were found. LOH at GADD45 locus was identified in 19/59 tumours. GADD45 does not appear to be a frequent mutational target in hereditary breast cancer.

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Authors and Affiliations

  1. Section of Oncogenetics, Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and University Hospital of Pisa, Italy

    Elisa Sensi, Mariella Tancredi, Paolo Aretini & Giovanna Cipollini

  2. Section of Oncogenetics, Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and University Hospital of Pisa, Italy

    Paola Collecchi, A. Giuseppe Naccarato, Paolo Viacava, Generoso Bevilacqua & Maria A. Caligo

Authors
  1. Elisa Sensi
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  2. Mariella Tancredi
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  3. Paolo Aretini
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  4. Giovanna Cipollini
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  5. Paola Collecchi
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  6. A. Giuseppe Naccarato
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  7. Paolo Viacava
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  8. Generoso Bevilacqua
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  9. Maria A. Caligo
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Sensi, E., Tancredi, M., Aretini, P. et al. Clinicopathological Significance of GADD45 Gene Alterations in Human Familial Breast Carcinoma. Breast Cancer Res Treat 87, 197–201 (2004). https://doi.org/10.1023/B:BREA.0000041625.60280.4a

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  • DOI: https://doi.org/10.1023/B:BREA.0000041625.60280.4a

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