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Polymer-coated liposomes resistant to enzymatic hydrolysis

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Abstract

A polymerizable electrolyte, 2-aminoethyl 1,6-heptadien-4-yl phosphate (AEHDP), which has the same hydrophilic head group as naturally occurring phospholipids, was prepared. Five equivalents of AEHDP were added to a suspension of liposomes (closed bilayer vesicles made of phospholipids) and layered on the liposomes. After polymerization by UV irradiation, the resulting polymer-coated liposomes were resistant to hydrolysis of their constituent phospholipids by phospholipase A2.

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Authors and Affiliations

  1. Department of Materials-Process Engineering & Applied Chemistry for Environments, Akita University, 1-1 Tegata Gakuen-cho, Akita, 010-8502, Japan

    Takeshi Gotoh

  2. Institute of Multidisciplinary Research for Advanced Material, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sdendai, 980-8577, Japan

    Mitsunori Hozawa

Authors
  1. Takeshi Gotoh
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  2. Mitsunori Hozawa
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Gotoh, T., Hozawa, M. Polymer-coated liposomes resistant to enzymatic hydrolysis. Biotechnology Letters 26, 611–614 (2004). https://doi.org/10.1023/B:BILE.0000021966.01506.5a

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  • DOI: https://doi.org/10.1023/B:BILE.0000021966.01506.5a

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