Abstract
Purpose : To compare pregnancy, implantation, and multiple gestation rates resulting from day 3 and day 5 embryo transfers after in vitro fertilization emphasizing a subset of patients who met criteria for day 5 transfer but elected to undergo day 3 transfer.
Method : A retrospective analysis of day 3 and day 5 embryo transfers from January 2001 to June 2002 were evaluated in a community teaching hospital setting. A total of 331 patients ≤40 years old were included. Using Student's t test, χ2test, and Fisher's exact test, we compared the pregnancy, implantation, and multiple gestation rates.
Results : Pregnancy, implantation, and multiple gestation rates were not significantly different between the subgroup who met criteria for day 5 embryo transfer but elected day 3 transfer. There was no significant difference between similar parameters in the overall comparison of day 3 versus day 5 embryo transfers.
Conclusions : Blastocyst transfers have similar multiple gestation rates, pregnancy rates, and implantation rates when compared to day 3 embryo transfers.
Similar content being viewed by others
REFERENCES
Luke B, Keith LG: The contribution of singletons, twins and triplets to low birth weight, infant mortality and handicap in the United States. J Reprod Med 1992;37:661–666
1999 Assisted Reproductive Technology Success Rates: National Summary and Fertility Clinic Reports. Bethesda, MD, Department of Health and Human Services (US), Centers for Disease Control and Prevention
Gardner DK, Schoolcraft WB, Wagley L, Schlenker T, Stevens J, Hesla J: A prospective randomized trial of blastocyst culture and transfer in in-vitro fertilization. Hum Reprod 1998;13:3434–3440
Karaki RZ, Samarraie SS, Younis NA, Lahloub RM, Ibrahim MH: Blastocyst culture and transfer: A step toward improved in vitro fertilization outcome. Fertil Steril 2002;77:114–118
Milki AA, Hinckley MD, Fisch JD, Dasig D, Behr: Comparison of blastocyst transfer with day 3 embryo transfer in similar patient populations. Fertil Steril 2000;73:126–129
Toledo AA, Wright G, Jones AE, Smith SS, Johnson-Ward J, Brockman WW, Ng F, Wininger D: Blastocyst transfer: A useful tool for reduction of high-order multiple gestations in a human assisted reproduction program. Am J Obstet Gynecol 200;183:377–382
Coskun S, Hollander J, Al-Hassan S, Al-Sufyan H, Al-Mayman H, Jaroudi K: Day 5 versus day 3 embryo transfer: A controlled randomized trial. Hum Reprod 2000;15:1947–1952
Rienzi L, Ubaldi F, Iacobelli M, Ferrero S, Minasi MG, Martinez F, Tesarik J, Greco E: Day 3 embryo transfer with combined evaluation at the pronuclear and cleavage stages compare favourably with day 5 blastocyst transfer. Hum Reprod 2002;17:1852–1855
Palermo GP, Cohen J, Alikani M, Adler A, Rosenwaks Z: Intracytoplasmic sperm injection:Anovel treatment for all forms of male infertility. Fertil Steril 1995;63:1231–1240
Cohen J, Alikani M, Trowbridge J, Rosenwaks Z: Implantation enhancement by selective assisted hatching using zona drilling of embryos with poor prognosis. Hum Reprod 1992;7:685–691
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Estes, S.J., Hoover, L.M., Smith, S.E. et al. Comparison of Pregnancy, Implantation, and Multiple Gestation Rates for Day 3 Versus Day 5 Embryo Transfers. J Assist Reprod Genet 20, 409–412 (2003). https://doi.org/10.1023/A:1026240827476
Issue Date:
DOI: https://doi.org/10.1023/A:1026240827476