Abstract
5-Amino-4-cyano-8-isobutyl-7-isopropyl-6-thiocarbamoyl-2-azabicyclo[2.2.2]oct-5-en-3-thione was synthesized by the condensation of isovaleryl aldehyde with cyanothioacetamide. The structure of the product was established by X-ray crystallography.
Similar content being viewed by others
REFERENCES
V. Ya. Grinshtein and L. A. Sherin', Izv. Akad. Nauk Latv. SSR, Ser. Khim., 469 (1963).
A. Gazit,P. Yaish,C. Gilton, and A. Levitzki, J. Med. Chem., 32, 2344 (1989).
D. Villemin and B. Martin, Synth. Commun., 23, 2259 (1993).
J. S. A. Brunskill,A. De, and D. F. Ewing, J. Chem. Soc., Perkin Trans. I., 629 (1978).
V. P. Litvinov, Uspekhi Khimii, 68, 817 (1999).
Ya. Ozols,B. Vigante, and G. Duburs, Khim. Geterotsikl. Soedin., 1603 (1994).
V. D. Dyachenko, Diss. Dokt. Khim. Nauk, Moscow (1998).
V. N. Nesterov,V. D. Dyachenko,Yu. A. Sharanin, and Yu. T. Struchkov, Izv. Akad. Nauk, Ser. Khim., 169 (1996).
N. S. Zefirov and V. A. Palyulin, Doklad. Akad. Nauk, 252, 111 (1980).
R. W. Alder,N. C. Goode,T. J. King,J. M. Mellor, and B. W. Miller, J. Chem. Soc., Chem. Commun., 173 (1976).
M. Burke-Laing and M. Laing, Acta Crystallogr., B32, 3216 (1976).
A. I. Kitaigorodskii, Molecular Crystals and Molecules. Acad. Press, New York, 431 (1973).
G. M. Sheldrick, SHELXS-86. Program for the Solution of Crystal Structures, University of Gottingen, Gottingen, Germany, 1986.
G. M. Sheldrick, SHELXL-93. Program for the Refinement of Crystal Structures, University of Gottingen, Gottingen, Germany, 1993.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dyachenko, V.D., Rusanov, E.B. Synthesis and Crystal Structure of 5-Amino-4-cyano-8-isobutyl-7-isopropyl-6-thiocarbamoyl-2-azabicyclo[2.2.2]oct-5-en-3-thione. Chemistry of Heterocyclic Compounds 39, 645–690 (2003). https://doi.org/10.1023/A:1025106401842
Issue Date:
DOI: https://doi.org/10.1023/A:1025106401842