Skip to main content
Log in

Synthesis and Crystal Structure of 5-Amino-4-cyano-8-isobutyl-7-isopropyl-6-thiocarbamoyl-2-azabicyclo[2.2.2]oct-5-en-3-thione

  • Published:
Chemistry of Heterocyclic Compounds Aims and scope

Abstract

5-Amino-4-cyano-8-isobutyl-7-isopropyl-6-thiocarbamoyl-2-azabicyclo[2.2.2]oct-5-en-3-thione was synthesized by the condensation of isovaleryl aldehyde with cyanothioacetamide. The structure of the product was established by X-ray crystallography.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

REFERENCES

  1. V. Ya. Grinshtein and L. A. Sherin', Izv. Akad. Nauk Latv. SSR, Ser. Khim., 469 (1963).

  2. A. Gazit,P. Yaish,C. Gilton, and A. Levitzki, J. Med. Chem., 32, 2344 (1989).

    Google Scholar 

  3. D. Villemin and B. Martin, Synth. Commun., 23, 2259 (1993).

    Google Scholar 

  4. J. S. A. Brunskill,A. De, and D. F. Ewing, J. Chem. Soc., Perkin Trans. I., 629 (1978).

    Google Scholar 

  5. V. P. Litvinov, Uspekhi Khimii, 68, 817 (1999).

    Google Scholar 

  6. Ya. Ozols,B. Vigante, and G. Duburs, Khim. Geterotsikl. Soedin., 1603 (1994).

  7. V. D. Dyachenko, Diss. Dokt. Khim. Nauk, Moscow (1998).

  8. V. N. Nesterov,V. D. Dyachenko,Yu. A. Sharanin, and Yu. T. Struchkov, Izv. Akad. Nauk, Ser. Khim., 169 (1996).

  9. N. S. Zefirov and V. A. Palyulin, Doklad. Akad. Nauk, 252, 111 (1980).

    Google Scholar 

  10. R. W. Alder,N. C. Goode,T. J. King,J. M. Mellor, and B. W. Miller, J. Chem. Soc., Chem. Commun., 173 (1976).

  11. M. Burke-Laing and M. Laing, Acta Crystallogr., B32, 3216 (1976).

    Google Scholar 

  12. A. I. Kitaigorodskii, Molecular Crystals and Molecules. Acad. Press, New York, 431 (1973).

    Google Scholar 

  13. G. M. Sheldrick, SHELXS-86. Program for the Solution of Crystal Structures, University of Gottingen, Gottingen, Germany, 1986.

    Google Scholar 

  14. G. M. Sheldrick, SHELXL-93. Program for the Refinement of Crystal Structures, University of Gottingen, Gottingen, Germany, 1993.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dyachenko, V.D., Rusanov, E.B. Synthesis and Crystal Structure of 5-Amino-4-cyano-8-isobutyl-7-isopropyl-6-thiocarbamoyl-2-azabicyclo[2.2.2]oct-5-en-3-thione. Chemistry of Heterocyclic Compounds 39, 645–690 (2003). https://doi.org/10.1023/A:1025106401842

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1025106401842

Navigation