Skip to main content
SpringerLink
Log in

The Energy Criterion for Quality of Immune Defence and Pathogenicity of Microorganisms

  • Published:
Automation and Remote Control Aims and scope Submit manuscript

Abstract

Relationships between the energy cost of immune defence, the disease severity, and the properties of pathogens were investigated. The findings suggested a hypothesis explaining the observed distribution of microorganism pathogenicity. The mechanism supporting stability of this distribution explains emergence of new highly pathogenic strains of microorganisms.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Gemmill, A.W. and Read, A.F., Counting the Cost of Disease Resistance, Trends Ecolog. Evolut., 1998, vol. 13, no.1, pp. 8-9.

    Google Scholar 

  2. Coustau, C., Chevillon, C., and ffrench-Constant, R., Resistance to Xenobiotics and Parasites: Can We Count the Cost?, Trends Ecolog. Evolut., 2000, vol. 15, no.9, pp. 378-383.

    Google Scholar 

  3. Verhulst, S., Dieleman, S.J., and Parmentier, H.K., A Trade-of Between Immunocompetence and Sexual Ornamentation in Domestic Fowl, Proc. Natl. Acad. Sci., 1999, vol. 96, pp. 4478-4481.

    Google Scholar 

  4. Kraaijeveld, A.R. and Godfray, H.C.J., Trade-of Between Parasitoid Resistance and Larval Competitive Ability in Drosophila Melanogaster, Nature, 1997, no. 389, pp. 278-280.

    Google Scholar 

  5. Sheldon, B.C. and Verhulst, S., Ecological Immunology: Costly Parasite Defences and Trade-offs in Evolutionary Ecology, Trends Ecolog. Evolut., 1996, vol. 11, no.8, pp. 317-321.

    Google Scholar 

  6. Timakov, V.D., Levashov, V.S., and Borisov, D.V., Mikrobiologiya: uchebnik (Manual of Microbiology), Moscow: Meditsina, 1983.

    Google Scholar 

  7. Stainer, R.Y., Adelberg, E.A., and Ingraham, J.L., The Microbial World, Englewood Cliffs: Prentice Hall, 1976. Translated under the title Mir mikrobov, Moscow: Mir, 1979.

    Google Scholar 

  8. Romanyukha, A.A. and Rudnev, S.G., Mathematical Modeling of Immune-Inammatory Processes in Lungs, Quest for Optimality, in Vychisl. mat. and mat. modelirovanie. Tr. mezhdunar. konf. (Proc. Int. Conf. "Numerical Mathematics and Mathematical Modeling"), Dymnikov, V.P., Ed., Moscow: Inst. Vychisl. Mat., 2000.

    Google Scholar 

  9. Marchuk, G.I., Matematicheskie modeli v immunologii (Mathematical Models in Immunology), Moscow: Nauka, 1991, 3rd ed.

    Google Scholar 

  10. Marchuk, G.I., Matematicheskie modeli v immunologii (Mathematical Models in Immunology), Moscow: Nauka, 1980.

    Google Scholar 

  11. Pontryagin, L.S., Obyknovennye differentsial'nye uravneniya (Ordinary Differential Equations), Moscow: Nauka, 1982.

    Google Scholar 

  12. Romanyukha, A.A., Energy Cost of Organism Anti-infectious Defence. An Evolutionary Approach to Data Analysis and Modeling, Tez. dokl. Vtoroi Sibirskii kongr. po prikl. i industrial'noi mat. (INPRIM-96) (Abstr. Second Siberian Congr. on Applied and Industrial Mathematics), Novosibirsk, 1996, p. 44.

  13. Fundamental Immunology, Paul, W.E., Ed., New York: Raven, 1984. Translated under the title Immunologiya Moscow: Mir, 1987-1989.

    Google Scholar 

  14. Ewald, P.W., Evolution of Infectious Disease, Oxford: Oxford Univ. Press, 1994.

    Google Scholar 

  15. Zhu, J., Quyyumi, A.A., et al., Effects of Total Pathogen Burden on Coronary Artery Disease Risk and C-reactive Protein Levels, Am. J. Cardiol., 2000, vol. 85, pp. 140-146.

    Google Scholar 

  16. Hacker, J. and Kaper, J.B., Pathogenicity Islands and the Evolution of Microbes, Ann. Rev. Micrbiol., 2000, vol. 54, pp. 641-679.

    Google Scholar 

  17. Hentschel, U. and Hacker, J., Pathogenicity Islands: The Tip of the Iceberg, Microbes Infection, 2001, vol. 3, no.7, pp. 545-548.

    Google Scholar 

  18. Wilson, M.E., Disease in Evolution. Introduction, Ann. New York Acad. Sci., 1994, vol. 740, pp. 1-12.

    Google Scholar 

  19. Murray, C.J.L. and Lopez, A.D., Evidence-based Health Policy—Lessons from the Global Burden of Disease Study, Science, 1996, vol. 1, no.274, pp. 740-743.

    Google Scholar 

  20. Antia, R., Levin, B.R., and May, R.M., Within-host Population Dynamics and the Evolution and Maintenance of Microparasite Virulence, Am. Nat., 1994, vol. 144, no.3, pp. 457-472.

    Google Scholar 

  21. Anderson, R.M. and May, R.M., Coevolution of Hosts and Parasites, Parasitology, 1982, vol. 85, no.2, pp. 411-426.

    Google Scholar 

  22. Anderson, R.M. and May, R.M., Population Biology of Infectious Diseases: Part 1, Nature, 1979, vol. 280, issue5721, no. 2, pp. 361-367.

    Google Scholar 

  23. May, R.M. and Anderson, R.M., Population Biology of Infectious Diseases: Part II, Nature, 1979, vol. 280, issue5722, no. 8, pp. 455-461.

    Google Scholar 

  24. Romanyukha, A.A. and Rudnev, S.G., Variational Principle in Studies of Anti-infectious Immunity as Exemplified by Pneumonia, Mat. Model., 2001, vol. 13, no.8, pp. 65-84.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Russian Academy of Sciences, Institute of Numerical Mathematics, Moscow, Russia

    A. S. Karkach & A. A. Romanyukha

Authors
  1. A. S. Karkach
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. A. Romanyukha
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Karkach, A.S., Romanyukha, A.A. The Energy Criterion for Quality of Immune Defence and Pathogenicity of Microorganisms. Automation and Remote Control 64, 975–984 (2003). https://doi.org/10.1023/A:1024193717170

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1024193717170

Keywords

Search

Navigation