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2-Chloro-3-quinolinecarboxaldehyde in the Synthesis of Condensed Quinoline Systems. 1. Synthesis of Derivatives of 3,4-Dihydro-2H-[1,3]thiazino[6,5-b]quinolines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A method for the synthesis of derivatives of previously unknown heterocyclic systems - 3,4-dihydro-2H-[1,3]thiazino[6,5-b]quinolines - has been developed based on 7,8-dimethyl-2-chloro-3-quinolinecarboxaldehyde via the consecutive steps of conversion into its Schiff's base with a primary amine, reduction to the corresponding aminomethyl derivative, conversion to the thiourea with isothiocyanates, and heterocyclization by intramolecular substitution of the chlorine atom.

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Authors and Affiliations

  1. ASINEKS, Moscow, 123182, Russia

    P. V. Kombarov

  2. M. V. Lomonosov Moscow State University, Moscow, 119234, Russia

    M. A. Yurovskaya

Authors
  1. P. V. Kombarov
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  2. M. A. Yurovskaya
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Kombarov, P.V., Yurovskaya, M.A. 2-Chloro-3-quinolinecarboxaldehyde in the Synthesis of Condensed Quinoline Systems. 1. Synthesis of Derivatives of 3,4-Dihydro-2H-[1,3]thiazino[6,5-b]quinolines. Chemistry of Heterocyclic Compounds 39, 364–367 (2003). https://doi.org/10.1023/A:1023975129116

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  • DOI: https://doi.org/10.1023/A:1023975129116

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