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An Evaluation of the Efficacy of In Vitro Fertilization with Intracytoplasmic Sperm Injection for Sperm with Low Hypoosmotic Swelling Test Scores and Poor Morphology

  • Matthew Check
  • Jerome H. Check
  • Donna Summers-Chase
  • Kimberly Swenson
  • Wei Yuan
Article

Abstract

Purpose: To corroborate or refute a previous study demonstrating that in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) is an effective therapy for infertility related to males with subnormal hypoosmotic swelling tests (HOST). The study would also determine if the copresence of poor morphology has any adverse effect on outcome.

Methods: Clinical and viable pregnancy rates and implantation rates were evaluated in a second series of patients. The data were further stratified according to whether the semen specimen demonstrated morphology using strict criteria <4% normal vs ≥4%.

Results: Clinical and viable pregnancy rates and implantation rates were 49.1, 45.3, and 23.4% for those with subnormal HOST scores and subnormal morphology vs 38.0, 34.3, and 22.5% for those with low HOST and strict morphology ≥4% (p = NS, chi-square analysis).

Conclusions: In vitro fertilization with ICSI is an effective therapy for infertility related to subnormal HOST scores. Poor morphology does not adversely affect the outcome.

Hypoosmotic swelling test intracytoplasmic sperm injection sperm morphology strict criteria 

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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Matthew Check
    • 1
  • Jerome H. Check
    • 1
  • Donna Summers-Chase
    • 1
  • Kimberly Swenson
    • 1
  • Wei Yuan
    • 1
  1. 1.Division of Reproductive Endocrinology & Infertility, Department of Obstetrics and Gynecology, Cooper Hospital/University Medical Center, Robert Wood Johnson Medical School at CamdenThe University of Medicine and Dentistry of New JerseyCamden

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