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Investigational New Drugs

, Volume 21, Issue 1, pp 113–129 | Cite as

Current Approaches to Novel Therapeutics in Pancreatic Cancer

  • Corina E. Akerele
  • Irina Rybalova
  • Howard L. Kaufman
  • Sridhar Mani
Article

Abstract

Pancreatic cancer is one of the most refractory neoplasms to medical treatment. Until now there has been only modest improvement in the treatment of this disease. Standards of care for combined-modality treatment of resectable as well as locally advanced, unresectable disease have not been uniformly accepted to date because of an equivocal or conflicting data. The inception of gemcitabine introduced the new era in the management of metastatic pancreatic cancer, however, new therapeutic approaches still need to be defined. The article discusses the current knowledge of the biology of this lethal disease, its impact on treatment options, and explores novel therapeutic modalities that are likely to improve outcomes and survival for patients in the future.

pancreatic cancer new therapeutic modalities 

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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Corina E. Akerele
    • 1
  • Irina Rybalova
    • 1
  • Howard L. Kaufman
    • 2
  • Sridhar Mani
    • 1
  1. 1.Albert Einstein Cancer CenterMontefiore Medical CenterBronx
  2. 2.Herbert Irving Cancer CenterColumbia Presbyterian Medical CenterNew YorkUSA

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