Abstract
Purpose: Ovarian endometriomas have an uncertain impact on outcome following in vitro fertilization (IVF). Some authors describe a poor response to ovulation induction, and others observe decreased pregnancy success rates. Conversely, IVF outcomes similar to those of patients undergoing IVF for tubal-factor infertility have also been reported. To determine the impact of ovarian endometriomas on pregnancy success in our IVF program, we identified patients with endometriosis and compared outcomes that were stratified by the presence or absence of an endometrioma at the time of follicular aspiration.
Methods: One hundred eight patients with a diagnosis of endometriosis treated with IVF were identified, retrospectively. In this group, 24 patients completed 29 cycles in which an ovarian endometrioma was aspirated at the time of oocyte retrieval, and 84 patients without endometriomas completed 147 cycles. The cycles from these two groups were compared for differences in peak estradiol, number of mature follicles, number of oocytes, number of embryos transferred, and clinical pregnancies.
Results: There were no significant differences between the two groups with respect to peak estradiol, mature follicles, number of oocytes, number of embryos transferred, or clinical pregnancies.
Conclusions: From this retrospective observational analysis it appears that aspiration of an endometrioma at the time of oocyte retrieval has no adverse effect on outcome. This information may prove helpful when faced with the decision to cancel an IVF treatment cycle in patients with this uncommon complication.
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REFERENCES
Olivennes F, Feldberg D, Liu HC, Cohen J, Moy F, Rosenwaks Z: Endometriosis: A stage by stage analysis—the role of in vitro fertilization. Fertil Steril 1995;64:392–398
Wardle PG, McLaughlin EA, McDermont A, Mitchell JD, Ray BD, Hall MGR: Endometriosis and ovulatory disorder: Reduced fertilization in vitro compared with tubal and unexplained infertility. Lancet 1985;2:236–239
Geber S, Paraschos T, Atkinson G, Margara R, Winston RM: Results of IVF in patients with endometriosis: The severity of the disease does not affect outcome, or the incidence of miscarriage. Hum Reprod 1995;10:1508–1511
Dicker D, Goldman JA, Feldberg D, Ashkenazi J, Levy T: Transvaginal ultrasonic needle-guided aspiration of endometriotic cysts before ovulation induction for in vitro fertilization. J In Vitro Fert Embryo Transfer 1991;8:286–289
Pagidas K, Falcone T, Hemmings R, Miron P: Comparison of reoperation for moderate (stage III) and severe (stage IV) endometriosis-related infertility with in vitro fertilization-embryo transfer. Fertil Steril 1996;65:791–795
Nezhat C, Winder W, Nezhat F: Is endoscopic treatment of endometriosis and endometrioma associated with better results than laparoscopy? Am J Gynecol Health 1988;2:10
Yaron Y, Peyser MR, Samuel D, Amit A, Lessing JB: Infected endometriotic cysts secondary to oocyte aspiration for in-vitro fertilization. Hum Reprod 1994;9:1759–1760
Padilla SL: Ovarian abscess following puncture of an endometrioma during ultrasound-guided oocyte retrieval. Hum Reprod 1993;8:1282–1293
Koninckx PR, Muyldermans M, Moerman P, Meuleman C, Deprest J, Cornille F: CA-125 concentrations in ovarian “chocolate” cyst fluid can differentiate an endometriotic cyst from a cystic corpus luteum. Hum Reprod 1992;7:1314–1317
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Isaacs, J.D., Hines, R.S., Sopelak, V.M. et al. Ovarian Endometriomas Do Not Adversely Affect Pregnancy Success Following Treatment With In Vitro Fertilization. J Assist Reprod Genet 14, 551–553 (1997). https://doi.org/10.1023/A:1022592715006
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DOI: https://doi.org/10.1023/A:1022592715006